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本文引用的文献
1
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Curr Opin Struct Biol. 2014 Dec;29:134-42. doi: 10.1016/j.sbi.2014.11.003. Epub 2014 Dec 3.
2
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Cancer Discov. 2014 Oct;4(10):1126-39. doi: 10.1158/2159-8290.CD-14-0358. Epub 2014 Aug 28.
3
Canonical non-homologous end joining in mitosis induces genome instability and is suppressed by M-phase-specific phosphorylation of XRCC4.
PLoS Genet. 2014 Aug 28;10(8):e1004563. doi: 10.1371/journal.pgen.1004563. eCollection 2014 Aug.
4
ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress.
Cell. 2014 Jul 31;158(3):633-46. doi: 10.1016/j.cell.2014.05.046.
5
Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis.
Biosci Rep. 2014 Jun 25;34(3):e00113. doi: 10.1042/BSR20140051.
6
ATM-mediated Mad1 Serine 214 phosphorylation regulates Mad1 dimerization and the spindle assembly checkpoint.
Carcinogenesis. 2014 Sep;35(9):2007-13. doi: 10.1093/carcin/bgu087. Epub 2014 Apr 11.
7
Mitosis inhibits DNA double-strand break repair to guard against telomere fusions.
Science. 2014 Apr 11;344(6180):189-93. doi: 10.1126/science.1248024. Epub 2014 Mar 20.
8
Non-homologous end joining: emerging themes and unanswered questions.
DNA Repair (Amst). 2014 May;17:2-8. doi: 10.1016/j.dnarep.2014.01.009. Epub 2014 Feb 26.
9
DNA damage: Dispersing Golgi.
Nat Rev Mol Cell Biol. 2014 Mar;15(3):153. doi: 10.1038/nrm3762.
10
Interplay between the DNA damage proteins MDC1 and ATM in the regulation of the spindle assembly checkpoint.
J Biol Chem. 2014 Mar 21;289(12):8182-93. doi: 10.1074/jbc.M113.532739. Epub 2014 Feb 7.
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