根治性切除治疗的Siewert II型癌患者复发的预测因素。

Factors predicting recurrence in patients with Siewert type II carcinoma treated with curative resection.

作者信息

Fukuchi Minoru, Mochiki Erito, Suzuki Okihide, Ishiguro Toru, Sobajima Jun, Onozawa Hisashi, Imaizumi Hideko, Shibata Kazue, Saito Kana, Naitoh Hiroshi, Kumagai Youichi, Ishibashi Keiichiro, Ishida Hideyuki

机构信息

Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan Department of Surgery, Gunma Chuo Hospital, Gunma, Japan

Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.

出版信息

Anticancer Res. 2015 Jan;35(1):505-9.

PMID:25550595

Abstract

AIM

To evaluate the recurrence risk for Siewert type II esophagogastric junction carcinoma treated with curative resection.

PATIENTS AND METHODS

We retrospectively analyzed clinicopathological and recurrence-free survival (RFS) data of 52 patients after curative resection for Siewert type II carcinoma focusing on the role of lymph node metastasis around the greater curvature or parapyloric area.

RESULTS

Recurrence was observed in 21 (40%) patients; the median time-to-recurrence was 11 months (range=3-33 months). According to multivariate Cox proportional hazard regression analysis, involvement of nodes no. 4sa, 4sb, 4d, 5 and/or 6 (odds ratio (OR)=6.62; 95% confidence interval (CI)=1.27-41.1; p=0.04) and younger age (OR=2.10; 95% CI=1.25-3.82; p<0.01) were significant independent risk factors affecting RFS.

CONCLUSION

Involvement of no. 4-6 nodes appears to predict recurrence of Siewert type II carcinoma treated with curative resection. Patients with this risk factor may benefit from effective use of perioperative chemotherapy.

摘要

目的

评估接受根治性切除的Siewert II型食管胃交界癌的复发风险。

患者与方法

我们回顾性分析了52例接受Siewert II型癌根治性切除术后患者的临床病理及无复发生存（RFS）数据，重点关注大弯侧或幽门旁区域淋巴结转移的作用。

结果

21例（40%）患者出现复发；复发的中位时间为11个月（范围=3 - 33个月）。根据多因素Cox比例风险回归分析，第4sa、4sb、4d、5和/或6组淋巴结受累（比值比（OR）=6.62；95%置信区间（CI）=1.27 - 41.1；p = 0.04）以及较年轻的年龄（OR = 2.10；95% CI = 1.25 - 3.82；p < 0.01）是影响RFS的显著独立危险因素。