Lv Wei-Ping, Han Ren-Feng, Shu Zhi-Rong
Department of Paediatrics, Yantaishan Hospital Yantai, Shandong, China.
Department of Paediatrics, The Affiliated Hospital of Qingdao University Qingdao, Shandong, China.
Int J Clin Exp Med. 2014 Nov 15;7(11):3924-32. eCollection 2014.
A meta-analysis was performed to comprehensively evaluate the correlations between the C3435T polymorphism of ABCB1 (the ATP-binding cassette, subfamily B, member 1 transporter gene) and drug resistance in epilepsy.
Inclusion and exclusion criteria and a strategy for searching original literature were developed and utilized to search Chinese and non-Chinese databases. Research reports discussing correlations between the ABCB1 C3435T polymorphism and patient responses to anti-epileptic drug (AED) therapy were collected. Comparisons and comprehensive quantitative analyses were conducted using an allele model (C vs. T), and a genotype model (CC vs. CT+TT). In addition, subgroup analyses were performed that divided the included studies according to the race of the study subjects (Asian or Caucasian), based on the geographical region in which each study was conducted.
The meta-analysis included a total of 23 publications that examined a total of 3,912 drug-resistant epileptic patients and 4,419 epileptic patients for whom drug treatment was effective. The included studies did not exhibit publication bias. Statistical analyses revealed that the C3435T polymorphism was not significantly correlated with drug resistance in epilepsy. The random-effects model comparing the C and T alleles produced an odds ratio (OR) of 1.10 with a 95% confidence interval (CI) of 0.98-1.25 and P = 0.46. Subgroup analyses suggested that in Caucasian population there are significant differences between resistance group (RN) and control group (N) in both allele model (C vsT: OR = 1.13; 95% CI: 1.03-1.25) and genotype model (CC vsCT+TT: OR = 1.27; 95% CI: 1.08-1.50).
The ABCB1 C3435T polymorphism is associated with drug resistance in epilepsy in Caucasian population.
进行一项荟萃分析，以全面评估ABCB1（ATP结合盒转运体B亚家族成员1转运蛋白基因）的C3435T多态性与癫痫耐药性之间的相关性。
制定纳入和排除标准以及检索原始文献的策略，并用于检索中文和非中文数据库。收集讨论ABCB1 C3435T多态性与患者对抗癫痫药物（AED）治疗反应之间相关性的研究报告。使用等位基因模型（C与T）和基因型模型（CC与CT + TT）进行比较和综合定量分析。此外，根据研究对象的种族（亚洲人或白种人），基于每项研究所在的地理区域，对纳入的研究进行亚组分析。
该荟萃分析共纳入23篇出版物，这些出版物共研究了3912例耐药癫痫患者和4419例药物治疗有效的癫痫患者。纳入的研究未表现出发表偏倚。统计分析表明，C3435T多态性与癫痫耐药性无显著相关性。比较C和T等位基因的随机效应模型产生的比值比（OR）为1.10，95%置信区间（CI）为0.98 - 1.25，P = 0.46。亚组分析表明，在白种人群中，等位基因模型（C与T：OR = 1.13；95% CI：1.03 - 1.25）和基因型模型（CC与CT + TT：OR = 1.27；95% CI：1.08 - 1.50）中，耐药组（RN）与对照组（N）之间均存在显著差异。
ABCB1 C3435T多态性与白种人群癫痫耐药性相关。
