生活方式建议随访可改善2型糖尿病患者的血糖控制、氧化还原和炎症状态。
Lifestyle advice follow-up improve glycemic control, redox and inflammatory status in patients with type 2 diabetes.
作者信息
Mahdad Nadia, Boukortt Farida Ouda, Benzian Zakaria, Bouchenak Malika
机构信息
Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences de la Nature et de la Vie, Université d'Oran, BP 1524 El M'Naouer, 31 000 Oran, Algeria.
Clinique Laribère, Centre Hospitalo-Universitaire CHU, 31 000 Oran, Algeria.
出版信息
J Diabetes Metab Disord. 2014 Dec 17;13(1):122. doi: 10.1186/s40200-014-0122-1. eCollection 2014.
BACKGROUND
The dietary composition associated to physical activity could play a significant role in improving insulin sensitivity and reducing risk of diabetes and its complications. This study was designed to investigate whether glycemic control, redox and inflammatory status impairments in patients with type 2 diabetes (T2D), were improved after 90 (d90) and 180 (d180) days follow-up of nutritional advices.
METHODS
Patients with T2D (n = 85) aged of 50 ± 8 years (Female/Male, 45/40), treated with oral antidiabetics (OAD) alone, with a body mass index (BMI) of 26 ± 2, were recruited. At the beginning of the study (d0), patients were instructed to follow-up nutritional advices adapted to T2D, and 30 to 45 min of walking per day. Assays were realized at d90 and d180 of follow-up. Data were compared by student 't' test and Pearson's correlation coefficients were determined between biochemical parameters and nutritional advices follow-up.
RESULTS
Reduced glycated haemoglobin (HbA1c), glucose and total cholesterol (TC) were noted in patients with T2D, at d90 and d180 compared to d0. Thiobarbituric acid reactive substances (TBARS) and hydroperoxyde levels were lower at d90 and d180 than d0. Serum nitric oxide (NO) was decreased at d180 compared to d0 and d90. In erythrocytes, superoxide dismutase (SOD) activity increased by 7% at d180 vs d0. Moreover, activity of glutathione peroxidase (GPx) enhanced (P < 0.05), whereas that of glutathione reductase (GRed) decreased (P < 0.001) at d90 vs d0. Resistin values were lower at d180 than d0 and d90 (P < 0.001). A progressive decrease in tumor necrosis factor-α (TNF-α) was observed at d90 and d180 vs d0.
CONCLUSION
Nutritional advices associated to physical activity improve glycemic control, serum TC, redox and inflammatory status in T2D, in particular after 3 months of counseling. However, these results need to be supported with a longer dietary treatment and more rigorous control during the follow-up.
背景
与体育活动相关的饮食组成可能在改善胰岛素敏感性、降低糖尿病及其并发症风险方面发挥重要作用。本研究旨在调查2型糖尿病（T2D）患者在接受营养建议90天（d90）和180天（d180）随访后，血糖控制、氧化还原和炎症状态的损害是否得到改善。
方法
招募年龄为50±8岁（女性/男性，45/40）、仅接受口服降糖药（OAD）治疗、体重指数（BMI）为26±2的T2D患者（n = 85）。在研究开始时（d0），指导患者遵循适合T2D的营养建议，并每天步行30至45分钟。在随访的d90和d180进行检测。通过学生t检验比较数据，并确定生化参数与营养建议随访之间的Pearson相关系数。
结果
与d0相比，T2D患者在d90和d180时糖化血红蛋白（HbA1c）、血糖和总胆固醇（TC）降低。在d90和d180时，硫代巴比妥酸反应性物质（TBARS）和氢过氧化物水平低于d0。与d0和d90相比，d180时血清一氧化氮（NO）降低。在红细胞中，与d0相比，d180时超氧化物歧化酶（SOD）活性增加7%。此外，与d0相比，d90时谷胱甘肽过氧化物酶（GPx）活性增强（P < 0.05），而谷胱甘肽还原酶（GRed）活性降低（P < 0.001）。与d0和d90相比，d180时抵抗素值较低（P < 0.001）。与d0相比，在d90和d180时观察到肿瘤坏死因子-α（TNF-α）逐渐降低。
结论
与体育活动相关的营养建议可改善T2D患者的血糖控制、血清TC、氧化还原和炎症状态，尤其是在咨询3个月后。然而，这些结果需要通过更长时间的饮食治疗和随访期间更严格的控制来支持。
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