促性腺激素释放激素可提高正常人体受试者的血浆7B2浓度。

LHRH increases plasma 7B2 concentration in normal human subjects.

作者信息

Natori S, Iguchi H, Ohashi M, Chrétien M, Nawata H

机构信息

Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

出版信息

Endocrinol Jpn. 1989 Jun;36(3):367-71. doi: 10.1507/endocrj1954.36.367.

DOI:10.1507/endocrj1954.36.367

PMID:2555142

Abstract

We studied the response of plasma 7B2 to LHRH and ovine corticotropin releasing hormone (o-CRH) in healthy young subjects. The plasma 7B2 concentration significantly increased from 78.3 +/- 7.5 (mean +/- SEM) to 102.0 +/- 6.0 ng/L (142.7 +/- 12.7% of the basal value; P less than 0.01) following iv administration of LHRH in seven young subjects. On the other hand, no increase in plasma 7B2 was found after iv administration of o-CRH in six young subjects. These results, together with our previous report of no increase in plasma 7B2 after administration of TRH and GHRH in young subjects, suggest that pituitary 7B2 may be present in gonadotrophs and be released only by LHRH in physiological conditions.

摘要

我们研究了健康年轻受试者血浆7B2对促性腺激素释放激素（LHRH）和羊促肾上腺皮质激素释放激素（o-CRH）的反应。在7名年轻受试者静脉注射LHRH后，血浆7B2浓度从78.3±7.5（平均值±标准误）显著增加至102.0±6.0 ng/L（为基础值的142.7±12.7%；P<0.01）。另一方面，在6名年轻受试者静脉注射o-CRH后，未发现血浆7B2增加。这些结果，连同我们之前关于年轻受试者注射促甲状腺激素释放激素（TRH）和生长激素释放激素（GHRH）后血浆7B2未增加的报告，提示垂体7B2可能存在于促性腺细胞中，且在生理条件下仅由LHRH释放。