Moran N, Jones E, O'Toole A, Murray F
Gastroenterology Department, Beaumont Hospital, Dublin.
Ir Med J. 2014 Nov-Dec;107(10):326-7.
Proton pump inhibitors (PPIs) are one of the most commonly prescribed groups of drug in Ireland, at great expense to the Irish healthcare executive. This study aims to evaluate the appropriateness of PPI prescriptions on admission and discharge in a tertiary referral hospital. All non-elective admissions in the Emergency Department in one week were included in the study. 102 patients in total were included, with 36 (35.4%) treated with a PPI on admission. Of these, only 3 (8.3%) had a clear indication noted as per current NICE guidelines. 18 new in-hospital PPI prescriptions were documented. 11 (61%) of which were present on discharge prescriptions. Continuing PPI prescription on discharge into the community may be inappropriate, costly and potentially harmful. Brief interventions aimed at reducing inappropriate PPI prescriptions have been shown to be effective at reducing the cost and potential harm of unnecessary treatment.
质子泵抑制剂（PPIs）是爱尔兰最常开具的药物类别之一，给爱尔兰医疗保健机构带来了巨大费用支出。本研究旨在评估一家三级转诊医院入院和出院时PPI处方的合理性。研究纳入了急诊科一周内所有非择期入院患者。总共纳入了102例患者，其中36例（35.4%）入院时接受了PPI治疗。在这些患者中，根据当前英国国家卫生与临床优化研究所（NICE）指南，只有3例（8.3%）有明确的用药指征。记录了18例新的住院期间PPI处方。其中11例（61%）出现在出院处方中。出院后继续在社区开具PPI处方可能不合适、成本高且有潜在危害。旨在减少不适当PPI处方的简短干预措施已被证明在降低不必要治疗的成本和潜在危害方面是有效的。
