Leri Annarosa, Rota Marcello, Pasqualini Francesco S, Goichberg Polina, Anversa Piero
From the Departments of Anesthesia and Medicine and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Circ Res. 2015 Jan 2;116(1):150-66. doi: 10.1161/CIRCRESAHA.116.303595.
This review article discusses the mechanisms of cardiomyogenesis in the adult heart. They include the re-entry of cardiomyocytes into the cell cycle; dedifferentiation of pre-existing cardiomyocytes, which assume an immature replicating cell phenotype; transdifferentiation of hematopoietic stem cells into cardiomyocytes; and cardiomyocytes derived from activation and lineage specification of resident cardiac stem cells. The recognition of the origin of cardiomyocytes is of critical importance for the development of strategies capable of enhancing the growth response of the myocardium; in fact, cell therapy for the decompensated heart has to be based on the acquisition of this fundamental biological knowledge.
这篇综述文章讨论了成年心脏中心肌生成的机制。这些机制包括心肌细胞重新进入细胞周期;已存在的心肌细胞去分化,这些细胞呈现出未成熟的复制细胞表型;造血干细胞向心肌细胞的转分化;以及源自驻留心脏干细胞激活和谱系特化的心肌细胞。认识心肌细胞的起源对于制定能够增强心肌生长反应的策略至关重要;事实上,针对失代偿心脏的细胞治疗必须基于这一基本生物学知识的获取。