Pemmaraju Naresh, Gill Javed, Krause John R
Department of Pathology, Section of Hematopathology, Baylor University Medical Center at Dallas and the Charles A. Sammons Cancer Center, Dallas, Texas.
Proc (Bayl Univ Med Cent). 2015 Jan;28(1):65-6. doi: 10.1080/08998280.2015.11929191.
Hairy cell leukemia (HCL) is an indolent neoplasm of small mature B lymphoid cells with characteristic morphologic features usually involving the peripheral blood, bone marrow, and spleen. It constitutes approximately 2% of adult leukemias and has a male predominance. Patients usually present with weakness, splenomegaly, and pancytopenia. The overall prognosis is favorable with appropriate treatment including purine analogs, interferon-alpha, and radiation. We report a patient with a history of breast cancer who presented with a left femoral lytic bone lesion that was subsequently diagnosed as HCL by morphology, immunohistochemistry, flow cytometry, and molecular genetic techniques. It was important to biopsy the lesion to establish the correct diagnosis, as HCL is a highly treatment-responsive malignancy.
毛细胞白血病（HCL）是一种小成熟B淋巴细胞的惰性肿瘤，具有特征性形态学特征，通常累及外周血、骨髓和脾脏。它约占成人白血病的2%，男性居多。患者通常表现为乏力、脾肿大和全血细胞减少。通过包括嘌呤类似物、α干扰素和放疗在内的适当治疗，总体预后良好。我们报告一例有乳腺癌病史的患者，其出现左股骨溶骨性骨病变，随后通过形态学、免疫组织化学、流式细胞术和分子遗传学技术诊断为HCL。对病变进行活检以确立正确诊断很重要，因为HCL是一种对治疗反应良好的恶性肿瘤。
