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险些误诊:毛细胞白血病

Almost a Near Miss: Hairy Cell Leukemia.

作者信息

Parkash Jasmita, Bansro Varinder, Chhabra Gurdeep S, Mujahid Zainab

机构信息

Internal Medicine, Dr. Rajendra Prasad Government Medical College, Himachal Pradesh, IND.

Internal Medicine, University of Maryland Capital Region Health, Largo, USA.

出版信息

Cureus. 2023 Jan 18;15(1):e33949. doi: 10.7759/cureus.33949. eCollection 2023 Jan.

Abstract

Hairy cell leukemia (HCL) is an infrequently encountered chronic B-lymphocyte hematological malignancy, which is found to be more prevalent in males. HCL can present with a myriad of nonspecific symptoms involving the reticuloendothelial system. Usually, patients are diagnosed after an incidental finding of pancytopenia. In the majority of cases, HCL follows an indolent course, and many patients remain asymptomatic. Treatment with nucleoside analogs is the first line of treatment and is indicated for patients with severe anemia, thrombocytopenia, neutropenia, or severe systemic symptoms. Here, we report an atypical case of a 41-year-old Hispanic female who presented with menorrhagia and iron deficiency anemia. She was diagnosed with HCL after a bone marrow biopsy demonstrated the characteristic "hairy projections."

摘要

毛细胞白血病(HCL)是一种罕见的慢性B淋巴细胞血液系统恶性肿瘤,在男性中更为常见。HCL可表现出涉及网状内皮系统的多种非特异性症状。通常,患者在偶然发现全血细胞减少后被诊断出来。在大多数情况下,HCL病程进展缓慢,许多患者没有症状。核苷类似物治疗是一线治疗方法,适用于患有严重贫血、血小板减少、中性粒细胞减少或严重全身症状的患者。在此,我们报告一例非典型病例,一名41岁的西班牙裔女性,表现为月经过多和缺铁性贫血。在骨髓活检显示出特征性的“毛状突起”后,她被诊断为HCL。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbd/9938344/af552805d056/cureus-0015-00000033949-i02.jpg

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