Porres-Aguilar Mateo, Rodriguez-Castro Carlos E, Osvaldo Padilla, Saifuddin Fátima, Siddiqui Tariq, Fan Jerry, Mukherjee Debabrata, Pema Kanchan, Abbas Aamer
Department of Internal Medicine (Porres-Aguilar, Rodriguez-Castro, Pema), the Department of Pathology (Osvaldo), and the Division of Cardiovascular Diseases (Siddiqui, Mukherjee, Abbas), Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas; medical student, Texas Tech University Health Sciences Center/Paul L. Foster School of Medicine, El Paso, Texas (Fan); and the Department of Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, Pakistan (Saifuddin).
Proc (Bayl Univ Med Cent). 2015 Jan;28(1):72-4. doi: 10.1080/08998280.2015.11929195.
Cryoglobulinemic vasculitis is a small vessel vasculitis that has been associated with chronic infections and autoimmune, lymphoproliferative, and neoplastic disorders. When no significant etiological factors are identified, it is called essential mixed cryoglobulinemia. A detailed and thorough laboratory investigation is required to exclude all possible causes of cryoglobulin formation. Although cryoglobulin testing is simple, careful temperature regulation is needed to avoid false-negative results. Consensus diagnosis should be developed and implemented for appropriate cryoglobulin detection and accurate clinical diagnosis for cryoglobulinemic vasculitis. Here we present an interesting, first-ever case report of a 54-year-old Hispanic-American woman with essential mixed cryoglobulinemia presenting with significant digital necrosis in association with membranous nephropathy.
冷球蛋白血症性血管炎是一种小血管血管炎，与慢性感染、自身免疫性、淋巴增殖性和肿瘤性疾病相关。当未发现明显的病因时，称为特发性混合性冷球蛋白血症。需要进行详细而全面的实验室检查以排除冷球蛋白形成的所有可能原因。尽管冷球蛋白检测很简单，但需要仔细调节温度以避免假阴性结果。应制定并实施共识诊断，以进行适当的冷球蛋白检测并对冷球蛋白血症性血管炎进行准确的临床诊断。在此，我们首次报告了一例有趣的病例，一名54岁的西班牙裔美国女性患有特发性混合性冷球蛋白血症，并伴有明显的指端坏死及膜性肾病。
