Institute for Brain and Neural Systems, Brown University;
Department of Physics, Brown University.
Dose Response. 2014 May 5;12(4):551-81. doi: 10.2203/dose-response.13-047.Antosh. eCollection 2014 Dec.
We investigate the biological effects of radiation using adult Drosophila melanogaster as a model organism, focusing on gene expression and lifespan analysis to determine the effect of different radiation doses. Our results support a threshold effect in response to radiation: no effect on lifespan and no permanent effect on gene expression is seen at incident radiation levels below 100 J/kg. We also find that it is more appropriate to compare radiation effects in flies using the absorbed energy rather than incident radiation levels.
我们使用成年黑腹果蝇作为模式生物来研究辐射的生物学效应,重点研究基因表达和寿命分析,以确定不同辐射剂量的影响。我们的结果支持辐射响应中的阈值效应:在入射辐射水平低于 100 J/kg 时,对寿命没有影响,对基因表达也没有永久影响。我们还发现,使用吸收能量而不是入射辐射水平来比较果蝇的辐射效应更为合适。