Wang Qingyu, Guo Caimao, Wang Tiantian, Shuai Peimeng, Wu Wenyu, Huang Shuqi, Li Yuanyuan, Zhao Pei, Zeng Chengkai, Yi Lan
Institute of Pharmacy and Pharmacology, Institute of Cytology and Genetics, The Hengyang Key Laboratory of Cellular Stress Biology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Arch Toxicol. 2025 Mar;99(3):851-863. doi: 10.1007/s00204-024-03933-w. Epub 2024 Dec 26.
In daily life, individuals are frequently exposed to various forms of radiation, which, when adhering to safety standards, typically result in relatively minor health effects. However, accidental exposure to radiation levels that exceed these safety standards can lead to significant health consequences. This study focuses on the analysis of radiation-induced damage to the nervous system and the mechanisms of pharmacological protection. The findings indicate that radiation can adversely affect neural structures, memory, and neurobehaviour. A range of pharmacological agents, including traditional Chinese medicine, Western medicine, and other therapeutic drugs, can be employed to safeguard the nervous system from radiation damage. The primary protective mechanisms of these agents encompass antioxidant effects, attenuation of apoptosis, and reduction of neurogenesis. A comprehensive review of these topics will offer new insights for the development and investigation of drugs aimed at mitigating radiation-induced damage to the nervous system.
在日常生活中，个体经常暴露于各种形式的辐射中，当符合安全标准时，通常只会产生相对较小的健康影响。然而，意外暴露于超过这些安全标准的辐射水平可能会导致严重的健康后果。本研究着重分析辐射对神经系统造成的损伤以及药理保护机制。研究结果表明，辐射会对神经结构、记忆和神经行为产生不利影响。一系列药理制剂，包括中药、西药和其他治疗药物，可用于保护神经系统免受辐射损伤。这些制剂的主要保护机制包括抗氧化作用、减轻细胞凋亡以及减少神经发生。对这些主题进行全面综述将为开发和研究旨在减轻辐射对神经系统损伤的药物提供新的见解。
