Stern Lauren, Havasi Andrea
Renal Section, Boston University School of Medicine, 650 Albany Str, 5th floor, Boston, MA, 02118.
Front Biosci (Elite Ed). 2015 Jan 1;7(1):149-57. doi: 10.2741/724.
Amyloidosis and monoclonal immunoglobulin deposition disease, though rare entities, can wreak havoc on the architecture and functioning of the kidneys. These diseases have a predilection to cause severe renal dysfunction leading to end stage renal disease (ESRD). In recent years, the available treatments for these diseases have expanded and afflicted patients are living longer, but with advanced kidney disease. Because of the complex nature of the pathophysiology and treatment of these diseases, it can be very challenging for a clinician to determine whether or not it is appropriate to refer an affected individual for kidney transplantation.
淀粉样变性和单克隆免疫球蛋白沉积病虽属罕见病症，但会严重破坏肾脏结构并影响其功能。这些疾病易导致严重肾功能不全，进而发展为终末期肾病（ESRD）。近年来，针对这些疾病的可用治疗方法有所增加，患病患者的寿命得以延长，但往往伴有晚期肾病。由于这些疾病的病理生理学和治疗较为复杂，临床医生很难判断将患病个体转诊进行肾移植是否合适。
