Dang Chao, Wei Bo, Long JianXiong, Zhou MengXiao, Han XinXin, Zhao TingTing
Department of Neurology and Stroke Center, the 1st Affiliated Hospital, Sun Yat-Sen University, No. 58 Zhongshan Rd 2, Guangzhou 510080, China.
Guangxi Food and Drug Administration, Road 22, Nanning, Guangxi Medical University, China 530021.
Int J Infect Dis. 2015 Apr;33:56-61. doi: 10.1016/j.ijid.2014.12.042. Epub 2014 Dec 30.
In 2012, more than 80,000 cases of HIV infection were recorded in the Southern Chinese minority autonomous region of Guangxi Zhuang, where the occurrence of HIV-associated dementia remains high. The International HIV Dementia Scale is a relatively simple-to-administer screening scale for HIV-associated neurocognitive disorders. However, clinical experience in utilizing the scale with large Chinese samples is currently lacking, especially among individuals with limited formal schooling. In this study, a full neuropsychological evaluation the gold standard was conducted to identify the incidence/prevalence of HIV-associated neurocognitive disorders in a socioeconomically underdeveloped region of Southern China and to locate the optimal cut-off scale value using receiver operating characteristic curves. The highest Youden index of the scale was 0.450, with a corresponding cut-off point of 7.25. The sensitivity and specificity were 0.737 and 0.713, respectively. These results suggest that the scale is an effective and feasible screening tool for HIV-associated neurocognitive disorders in poorer regions of China with fewer well-educated residents.
2012年，中国南部壮族少数民族自治区广西记录了8万多例艾滋病毒感染病例，该地区与艾滋病毒相关的痴呆症发病率仍然很高。国际艾滋病毒痴呆量表是一种用于筛查与艾滋病毒相关的神经认知障碍的相对易于实施的量表。然而，目前缺乏在中国大样本中使用该量表的临床经验，尤其是在受正规教育程度有限的个体中。在本研究中，进行了全面的神经心理学评估（金标准），以确定中国南部一个社会经济欠发达地区与艾滋病毒相关的神经认知障碍的发病率/患病率，并使用受试者工作特征曲线确定最佳截断量表值。该量表的最高约登指数为0.450，相应的截断点为7.25。敏感性和特异性分别为0.737和0.713。这些结果表明，该量表是在中国居民受教育程度较低的贫困地区筛查与艾滋病毒相关的神经认知障碍的有效且可行的工具。
