Kawaguchi H, Sawa H, Yasuda H
Department of Cardiovascular Medicine, Hokkaido University, School of Medicine, Sapporo, Japan.
J Mol Cell Cardiol. 1989 Oct;21(10):959-61. doi: 10.1016/0022-2828(89)90794-3.
We studied the effects of atrial natriuretic factor on the conversion of angiotensin I to angiotensin II. Atrial natriuretic factor had a novel effect on angiotensin I conversion. Pulmonary artery endothelial cells converted 1.22 nmol/min/dish of [125I]angiotensin I to II in the absence of atrial natriuretic factor, but this activity was suppressed by atrial natriuretic factor. When atrial natriuretic factor was added to pulmonary artery endothelial cells, the conversion of angiotensin I to angiotensin II was suppressed 0.475 nmol/min/dish at 10(-6) M of atrial natriuretic factor.
我们研究了心房利钠因子对血管紧张素I转化为血管紧张素II的影响。心房利钠因子对血管紧张素I的转化有新的作用。在没有心房利钠因子的情况下，肺动脉内皮细胞每分钟每平皿将1.22纳摩尔的[125I]血管紧张素I转化为血管紧张素II，但这种活性被心房利钠因子抑制。当将心房利钠因子添加到肺动脉内皮细胞中时，在10(-6)M的心房利钠因子作用下，血管紧张素I向血管紧张素II的转化被抑制至每分钟每平皿0.475纳摩尔。
