Talati Chetasi, Ontiveros Evelena P, Griffiths Elizabeth A, Wang Eunice S, Wetzler Meir
Internal Medicine, University at Buffalo, Buffalo, NY, USA.
Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
Blood Rev. 2015 Mar;29(2):137-42. doi: 10.1016/j.blre.2014.12.003. Epub 2014 Dec 17.
Imatinib will become generic in 2016; assuming that its price will decrease precipitously, we expect that the economic forces will change our current practice habits. We reviewed the literature on the current recommendations to treat chronic myeloid leukemia and highlight how we plan to deal with these changes. Specifically, we propose to better characterize patients according to prognostic scores, to allow more attention to those at high risk for disease progression, e.g., 3-month guidelines and BCR/ABL1 message half-time, emphasize compliance by using contemporary technologies, and increase the importance of early monitoring. We hope that our message will open communication between providers, insurance companies and healthcare authorities to offer the best care for our patients.
伊马替尼将于2016年成为非专利药;假定其价格将大幅下降,我们预计经济因素将改变我们目前的治疗习惯。我们回顾了关于治疗慢性髓性白血病的当前建议的文献,并强调了我们计划如何应对这些变化。具体而言,我们建议根据预后评分更好地对患者进行特征描述,以便更多关注疾病进展高危患者,例如3个月指南和BCR/ABL1信息半衰期,利用当代技术强调依从性,并提高早期监测的重要性。我们希望我们传达的信息将开启医疗服务提供者、保险公司和卫生当局之间的沟通,以便为我们的患者提供最佳护理。