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经尿道铥激光前列腺剜除术治疗前列腺增生症:215 例报告

Photoselective Vaporesection of the Prostate with a Front-firing Lithium Triborate Laser: Surgical Technique and Experience After 215 Procedures.

机构信息

Department of Urology, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.

Department of Urology, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.

出版信息

Eur Urol. 2015 Jun;67(6):1152-1159. doi: 10.1016/j.eururo.2014.12.021. Epub 2014 Dec 30.

Abstract

BACKGROUD

Although photoselective vaporization of the prostate (PVP) is considered one of the most promising alternatives to transurethral radical prostatectomy, a longer operative time, an unsatisfactory tissue removal rate, and the absence of postoperative pathology samples remain the main criticisms for this procedure.

OBJECTIVE

To describe the novel technique of photoselective vaporesection of the prostate (PVRP) with a front-firing lithium triborate (LBO) laser and to report our initial experience.

DESIGN, SETTING, AND PARTICIPANTS: This is a prospective study of 215 patients undergoing PVRP between November 2011 and March 2013. Their average age, prostate size, and International Prostate Symptom Score (IPSS) were 70.3 ± 7.3 yr, 70.4 ± 34.0 ml, and 24.9 ± 5.0, respectively.

SURGICAL PROCEDURE

The operative technique is detailed in the accompanying video.

OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS

Perioperative data were collected. The patients were followed up at 3, 6, 12 mo after PVRP, and functional outcomes and complications were assessed.

RESULTS AND LIMITATIONS

The mean operation time was 44.1 ± 22.6 min. The mean hemoglobin decrease was 0.37 ± 0.21 g/dl. The catheterization time was 23.9 ± 15.2 h and the postoperative hospital stay was 1.8 ± 0.8 d. Significant improvements were observed in maximum flow, IPSS, and postvoid residual urine at each follow-up time point. Compared to preoperative values, prostate volume and serum prostate-specific antigen fell by 67% and 63%, respectively, at 3 mo after PVRP. No major complications were noted. Application of a hemostat for a front-firing LBO laser makes it easy to handle intractable intraoperative bleeding. The main limitation of this study is the short follow-up period. The influence of PVRP on sexual function and the learning curve remain to be evaluated.

CONCLUSIONS

PVRP is a novel technique that is effective and safe for treatment of benign prostatic hyperplasia. This technique retains the excellent hemostatic property of LBO lasers and has a short operation time and a high tissue removal rate. The problem of the lack of postoperative tissue samples for PVP is also overcome in PVRP.

PATIENT SUMMARY

We have developed a novel technique named photoselective vaporesection of the prostate (PVRP) with a front-firing green laser. Our results show that PVRP retains the excellent hemostatic property of a green laser, but has a much shorter operation time and a higher rate of tissue removal than photoselective vaporization of the prostate (PVP). This technique also solves the problem of the lack of postoperative tissue specimens and the difficulty of handling intractable intraoperative bleeding. According to our initial results, PVRP is a novel technique superior to PVP in the treatment of benign prostatic hyperplasia.

摘要

背景

虽然经尿道选择性前列腺汽化术(PVP)被认为是经尿道前列腺切除术的最有前途的替代方法之一,但较长的手术时间、不理想的组织切除率以及缺乏术后病理样本仍然是该手术的主要批评点。

目的

描述一种新型的经尿道选择性前列腺汽化术(PVRP)技术,该技术使用前发射式硼锂酸铌(LBO)激光,并报告我们的初步经验。

设计、设置和参与者:这是一项对 215 例 2011 年 11 月至 2013 年 3 月期间接受 PVRP 治疗的患者进行的前瞻性研究。他们的平均年龄、前列腺大小和国际前列腺症状评分(IPSS)分别为 70.3 ± 7.3 岁、70.4 ± 34.0ml 和 24.9 ± 5.0。

手术过程

手术技术在随附的视频中详细介绍。

手术结果和统计分析

收集围手术期数据。患者在 PVRP 后 3、6、12 个月进行随访,评估功能结果和并发症。

结果和局限性

平均手术时间为 44.1 ± 22.6 分钟。平均血红蛋白下降 0.37 ± 0.21 g/dl。导管时间为 23.9 ± 15.2 小时,术后住院时间为 1.8 ± 0.8 天。在每次随访时,最大流量、IPSS 和残余尿量均有显著改善。与术前相比,前列腺体积和血清前列腺特异性抗原分别下降了 67%和 63%,在 PVRP 后 3 个月。未发现主要并发症。应用止血夹处理前发射式 LBO 激光可轻松处理术中难以控制的出血。本研究的主要局限性是随访时间较短。PVRP 对性功能的影响和学习曲线仍有待评估。

结论

PVRP 是一种治疗良性前列腺增生症的有效且安全的新技术。该技术保留了 LBO 激光的出色止血性能,且具有较短的手术时间和较高的组织切除率。PVRP 还克服了 PVP 术后缺乏组织样本的问题。

患者总结

我们开发了一种新型的经尿道选择性前列腺汽化术(PVRP)技术,该技术使用前发射式绿光激光。我们的结果表明,PVRP 保留了绿光激光出色的止血性能,但手术时间更短,组织切除率更高,优于经尿道选择性前列腺汽化术(PVP)。该技术还解决了术后组织标本缺乏和难以处理术中难以控制的出血的问题。根据我们的初步结果,PVRP 是一种优于 PVP 的治疗良性前列腺增生症的新技术。

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