Kerne Valerie, Chapieski Lynn
Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA; Section of Psychology, Texas Children's Hospital, 6701 Fannin, CC-1630, Houston, TX 77030, USA.
Epilepsy Behav. 2015 Feb;43:48-52. doi: 10.1016/j.yebeh.2014.11.030. Epub 2014 Dec 31.
Young people with epilepsy are less likely to achieve the level of independence attained by their peers. We examined the seizure-related variables that placed a group of 97 pediatric patients with intractable seizures at risk for poor adaptive functioning. Analyses evaluated both the direct effects of the medical variables and indirect effects that were mediated through increased parental anxiety about their child's epilepsy. Higher numbers of anticonvulsants, presence of seizures that secondarily generalize, longer duration of seizure disorder, and younger age at onset were all identified as risk factors for poor adaptive functioning. Depending on the specific behavioral domain of adaptive functioning, the effects were sometimes direct and sometimes indirect. Lower levels of parental education and positive family history of seizures were associated with higher levels of parental anxiety. Interventions that target parental anxiety about seizures may mitigate the deleterious effects of epilepsy on social development.
患有癫痫的年轻人实现同龄人所达到的独立水平的可能性较小。我们研究了与癫痫发作相关的变量，这些变量使一组97名患有顽固性癫痫的儿科患者面临适应功能不良的风险。分析评估了医学变量的直接影响以及通过父母对孩子癫痫的焦虑增加而介导的间接影响。抗惊厥药物数量较多、继发性全身性发作的存在、癫痫发作障碍的持续时间较长以及发病年龄较小均被确定为适应功能不良的风险因素。根据适应功能的具体行为领域，这些影响有时是直接的，有时是间接的。父母教育水平较低和癫痫的阳性家族史与父母较高的焦虑水平相关。针对父母对癫痫发作的焦虑的干预措施可能会减轻癫痫对社会发展的有害影响。
