Voĭtiuk A A, Blizniuk A A
Mol Biol (Mosk). 1989 Jul-Aug;23(4):1107-12.
The influence of protonation on the relative stability of matched and mismatched nucleic base pairs was considered. Protonation of a base has a significant effect on the bond energy and, in some cases, on the geometry of pairs. It was shown that protonation of guanine, adenine and uracil lead to an increased relative stability of matched pairs and, consequently, to decreased probability of mutations. Protonation of cytosine reduced the difference in energy formation of GC and AC complexes.
考虑了质子化对匹配和错配核酸碱基对相对稳定性的影响。碱基的质子化对键能有显著影响，在某些情况下，也会对碱基对的几何结构产生影响。结果表明，鸟嘌呤、腺嘌呤和尿嘧啶的质子化导致匹配碱基对的相对稳定性增加，从而降低了突变的概率。胞嘧啶的质子化减少了GC和AC复合物形成能量的差异。
