Inoue Akihiro, Kohno Shohei, Kumon Yoshiaki, Watanabe Hideaki, Ohnishi Takanori, Hashimoto Hisashi, Matsubara Keiichi
Department of Neurosurgery, Ehime University School of Medicine.
No Shinkei Geka. 2015 Jan;43(1):57-62. doi: 10.11477/mf.1436202946.
We report herein a case of cerebellar hemangioblastoma complicated by pregnancy and concerns about the period in which surgery could be performed successfully. A 19-year-old woman, who was also 35 weeks pregnant, was admitted to our hospital with headache, nausea, and general fatigue. Neurological examination on admission revealed disturbed consciousness, and the patient's general condition was poor. Computed tomography and magnetic resonance imaging showed a large tumor in the cerebellar vermis along with an obstructive hydrocephalus. Computed tomographic angiography with three-dimensional reconstruction revealed feeding arteries and a draining vein in this tumor. Based on the clinical features, hemangioblastoma was suspected, and surgical excision and extraction of the fetus were scheduled. However, because of rapid neurological deterioration due to tumor progression, an emergency cesarean section was performed under general anesthesia. After extracting the fetus, the level of consciousness improved, so a tumor resection was planned after the patient's general condition improved. However, the neurological state deteriorated again due to the worsening hydrocephalus, which was suspected to be caused by the increased cerebral blood flow following uterine contraction. Emergency surgery for the brain tumor was performed two days after delivery. The tumor was resected completely and histopathological examination confirmed a diagnosis of hemangioblastoma. The postoperative course was uneventful, and the patient and newborn were discharged with no neurological deficits three weeks after the operation. This case suggested that if we encounter patients with brain tumors complicated by pregnancy, not only is earlier diagnosis from clinical features important, but also persistent additional treatment should be carried out without delay to effectively control intracranial pressure.
我们在此报告一例妊娠合并小脑成血管细胞瘤的病例以及关于能够成功进行手术的时期的相关问题。一名19岁、怀孕35周的女性因头痛、恶心和全身乏力入住我院。入院时的神经系统检查发现意识障碍,患者的一般状况较差。计算机断层扫描和磁共振成像显示小脑蚓部有一个大肿瘤以及梗阻性脑积水。三维重建的计算机断层血管造影显示该肿瘤有供血动脉和引流静脉。根据临床特征,怀疑为成血管细胞瘤,并计划进行手术切除及取出胎儿。然而,由于肿瘤进展导致神经功能迅速恶化,遂在全身麻醉下进行了急诊剖宫产。取出胎儿后,意识水平有所改善,因此计划在患者一般状况改善后进行肿瘤切除。然而,由于脑积水恶化,神经状态再次恶化,怀疑是子宫收缩后脑血流量增加所致。产后两天对脑肿瘤进行了急诊手术。肿瘤被完全切除,组织病理学检查确诊为成血管细胞瘤。术后过程顺利,患者和新生儿在术后三周出院,无神经功能缺损。该病例表明,如果我们遇到妊娠合并脑肿瘤的患者,不仅从临床特征进行早期诊断很重要,而且应毫不延迟地持续进行额外治疗以有效控制颅内压。