Raju U, Kini R, Warrier R
Department of Pathology, Henry Ford Hospital, Detroit, Michigan.
Mod Pathol. 1989 Nov;2(6):681-6.
We report the clinicopathological and ultrastructural features of a primitive embryonal tumor which occurred as a polypoid mass in the nasal cavity of a newborn infant. Its primitive-appearing, glycogen-rich, small round cells exhibited epithelial characteristics histologically, immunohistochemically, and ultrastructurally. The tumor was initially diagnosed as embryonal carcinoma because of evidence for endodermal differentiation and lack of specific features of other types of small round cell tumors of childhood. However, it did not have the characteristic features of endodermal sinus tumor nor the anaplasia of the adult type of embryonal carcinoma. It had some resemblance to embryonic somatic tissues and the blastemal component of some of the primitive tumors of childhood. Because of its unique morphological appearance, which has never been reported, and its relatively indolent behavior after chemotherapy and radiotherapy, we believe that this is a distinctive primitive teratoid tumor which may be classified as nasal blastoma.
我们报告了一例发生于新生儿鼻腔的息肉样肿物的原始胚胎性肿瘤的临床病理及超微结构特征。其形态原始、富含糖原的小圆形细胞在组织学、免疫组织化学及超微结构上均表现出上皮特征。该肿瘤最初因有内胚层分化证据且缺乏儿童期其他类型小圆形细胞肿瘤的特异性特征而被诊断为胚胎癌。然而，它既不具有内胚窦瘤的特征性表现，也没有成人型胚胎癌的间变表现。它与胚胎体细胞组织以及儿童期某些原始肿瘤的胚基成分有一定相似性。鉴于其从未被报道过的独特形态外观，以及化疗和放疗后相对惰性的行为，我们认为这是一种独特的原始畸胎样肿瘤，可归类为鼻母细胞瘤。
