在六个月大的婴儿中，产前暴露于母亲的焦虑情绪与发育较不完善的平稳跟踪眼球运动有关：一项初步研究。

In Six-month-old Infants, Prenatal Exposure to Maternal Anxiety is Associated with Less Developed Smooth Pursuit Eye Movements: An Initial Study.

作者信息

Pellegrino Laurel, Ross Randal G, Hunter Sharon K

机构信息

Department of Psychiatry, University of Colorado Denver, Campus Box F546, 13001 E 17 Pl, Aurora, CO 80045, USA ; School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Department of Psychiatry, University of Colorado Denver, Campus Box F546, 13001 E 17 Pl, Aurora, CO 80045, USA.

出版信息

Int Neuropsychiatr Dis J. 2013;1(1):89-103. doi: 10.9734/INDJ/2013/5174.

DOI:10.9734/INDJ/2013/5174

PMID:25558459

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4280661/

Abstract

AIMS

There are an increasing number of reports suggesting an association between maternal anxiety experienced during pregnancy and adverse outcomes of the offspring. However, exploration of the biological changes in the brain that mediate that relationship has been hampered by the lack of appropriate biomarkers. This report represents an initial step exploring whether a potential infant biomarker, smooth pursuit eye movements, may be associated with prenatal exposure to maternal anxiety.

STUDY DESIGN

Blinded cross-sectional study.

PLACE AND DURATION OF STUDY

Department of Psychiatry, University of Colorado School of Medicine. Data collected from July 2011 to May 2012.

METHODOLOGY

Forty-three infants including 34 whose prenatal maternal anxiety status was identified (12 with a known maternal prenatal anxiety diagnosis and 22 without) had eye movements recorded during a smooth pursuit eye movement task at four and/or six months of age.

RESULTS

At 6 months of age, infants with prenatal exposure to maternal anxiety, compared to infants without such exposure, spent a higher percentage of time utilizing smooth pursuit (t=2.7, df=24, =.013), had longer duration of smooth pursuit uninterrupted by saccades (t=2.5, df=24, =.019), and had decreased frequency of forward saccades (t=3.8, df=24, =.001). No differences between groups were identified at 4 months of age.

CONCLUSION

Smooth pursuit abnormalities may, at six months of age, be a potential biomarker for prenatal maternal anxiety exposure.

摘要

目的

越来越多的报告表明，孕期母亲经历的焦虑与后代的不良后果之间存在关联。然而，由于缺乏合适的生物标志物，介导这种关系的大脑生物学变化的探索受到了阻碍。本报告是探索一种潜在的婴儿生物标志物——平稳跟踪眼球运动是否可能与产前暴露于母亲焦虑有关的初步步骤。

研究设计

盲法横断面研究。

研究地点和时间

科罗拉多大学医学院精神病学系。2011年7月至2012年5月收集的数据。

方法

43名婴儿，其中34名婴儿的产前母亲焦虑状态已确定（12名母亲有产前焦虑诊断，22名没有），在4个月和/或6个月大时，在平稳跟踪眼球运动任务中记录眼球运动。

结果

在6个月大时，与未暴露于母亲焦虑的婴儿相比，产前暴露于母亲焦虑的婴儿在使用平稳跟踪方面花费的时间百分比更高（t = 2.7，自由度 = 24，P = 0.013），平稳跟踪不受扫视干扰的持续时间更长（t = 2.5，自由度 = 24，P = 0.019），向前扫视的频率降低（t = 3.8，自由度 = 24，P = 0.001）。在4个月大时未发现组间差异。