Department of Neurology, China Medical University Hospital No. 1, Shenyang, Liaoning Province, P.R. China.
Turk J Med Sci. 2014;44(3):353-9. doi: 10.3906/sag-1301-2.
Though social anxiety and social recognition have been studied extensively, the roles of the medial or basolateral amygdala in the control of social anxiety and social recognition remain to be determined. This study investigated the effects of excitotoxic bilateral medial or basolateral amygdala lesions upon social anxiety and social recognition in-mice.
Animals at 9 weeks of age were given bilateral medial or basolateral amygdala lesions via infusion of N-methyl- D-aspartate and then were used for behavioral tests: anxiety-related tests (including open-field test, light-dark test, and elevated-plus maze test), social behavior test in a novel environment, social recognition test, and flavor recognition test.
Medial or basolateral amygdala-lesioned mice showed lower levels of anxiety and increased social behaviors in a novel environment. Destruction of the medial or basolateral amygdala neurons impaired social recognition but not flavor recognition.
The medial or basolateral amygdala is involved in the control of anxiety-related behavior (social anxiety and social behaviors) in mice. Moreover, both the medial and the basolateral amygdala are essential for social recognition but not flavor recognition in mice.
尽管社交焦虑和社会认知已经得到了广泛的研究，但内侧或基底外侧杏仁核在控制社交焦虑和社会认知方面的作用仍有待确定。本研究探讨了兴奋性双侧内侧或基底外侧杏仁核损伤对小鼠社交焦虑和社会认知的影响。
9 周龄动物通过给予 N-甲基-D-天冬氨酸双侧内侧或基底外侧杏仁核损伤，然后进行行为测试：焦虑相关测试（包括旷场试验、明暗试验和高架十字迷宫试验）、新环境中的社交行为测试、社会认知测试和味觉识别测试。
内侧或基底外侧杏仁核损伤的小鼠表现出较低水平的焦虑和在新环境中增加的社交行为。内侧或基底外侧杏仁核神经元的破坏损害了社会认知，但不损害味觉识别。
内侧或基底外侧杏仁核参与了控制小鼠的焦虑相关行为（社交焦虑和社交行为）。此外，内侧和基底外侧杏仁核对于小鼠的社会认知都是必不可少的，但对于味觉识别则不是。
