Adamec R E, Morgan H D
Department of Psychology and Basic Medical Science, Memorial University, St. John's, Newfoundland, Canada.
Physiol Behav. 1994 Jan;55(1):1-12. doi: 10.1016/0031-9384(94)90002-7.
The effects on rodent anxiety of kindling in the medial or basolateral amygdaloid nuclei in each hemisphere were examined. Anxiety was measured using the hole board and elevated plus maze tests. The animals were kindled in medial or basolateral amygdalas, of either the left or right hemisphere. Controls had electrodes implanted in comparable areas, but were not kindled. Analysis of electrode location showed that some animals were kindled in amygdaloid nuclei other than medial or basolateral amygdala. These animals were labelled outliers. Kindling of the medial/basolateral amygdala in the left hemisphere decreased anxiety for at least 1 week after the last kindled seizure. Right hemisphere medial/basolateral kindling tended to increase anxiety. Outlier-kindled rats were less anxious than their controls regardless of hemisphere 1 week after their last kindled seizure. Clear anxiogenic effects were not likely seen in the right hemisphere in this study because of the electrode locations. The degree of anxiety following kindling was correlated with electrode location in the anterior-posterior plane. More anterior foci in the amygdala were associated with more anxiety. More posterior amygdala foci were associated with less anxiety. These findings point to the importance of kindled focus in the amygdala for behavioral effect. Future research should carefully control the location of kindled foci when investigating effects of amygdala kindling on anxiety and other behaviors.
研究了点燃每侧半球内侧或基底外侧杏仁核后对啮齿动物焦虑的影响。使用洞板试验和高架十字迷宫试验测量焦虑水平。动物在左侧或右侧半球的内侧或基底外侧杏仁核进行点燃。对照组在相应区域植入电极，但未进行点燃。电极位置分析表明，一些动物在除内侧或基底外侧杏仁核以外的杏仁核核团被点燃。这些动物被标记为异常值。在最后一次点燃发作后至少1周，左侧半球内侧/基底外侧杏仁核的点燃降低了焦虑。右侧半球内侧/基底外侧杏仁核的点燃倾向于增加焦虑。在最后一次点燃发作1周后，无论半球如何，异常值点燃的大鼠比其对照组焦虑程度更低。由于电极位置的原因，在本研究中右侧半球不太可能出现明显的致焦虑效应。点燃后的焦虑程度与电极在前后平面的位置相关。杏仁核中更靠前的病灶与更多焦虑相关。杏仁核中更靠后的病灶与更少焦虑相关。这些发现表明杏仁核中点燃病灶对行为效应的重要性。未来的研究在调查杏仁核点燃对焦虑和其他行为的影响时，应仔细控制点燃病灶的位置。
