Parahuleva N, Pehlivanov B, Orbecova M, Uchikova E, Ivancheva H
Akush Ginekol (Sofiia). 2014;53(5):22-7.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and the leading cause of oligo/anovulatory infertility. The incidence of PCOS in the population is 5-10% depending on the phenotypic expression of the syndrome as use criteria for diagnosis Anti- Mullerian Hormone may be defined as a glycoprotein growth factor having autocrine and paracrine deystvie. Prodused in granulosa cells of the ovary and related to the growth and development of follicles. Studies devoted to the relationship between AMH and PCOS and hormone levels in the main phenotypes of PCOS are conflicting and few.
Comparison of the serum levels of Anti-Mullerian Hormone (AMH) in major phenotypes of polycystic ovarian syndrome (A, B, C, D). As to study of correlation between serum levels of anti-Mullerian Hormone (AMH) and the other hormonal parameters
Prospective comparative study.
Material and Methods. This study was conducted in the Department of Obstetrics and Gynecology, University Hospital St. George, Plovdiv and Clinic of Endocrinology, University Hospital St. George - Plovdiv. We studied 100 women aged between 18-35 years with polycystic ovary syndrome (PCOS) have been selected according to the criteria of the American Society of Reproductive Medicine (ASRM) - Rotterdam, 2003. Distributed by phenotypic characterization into four groups: Phenotype A (OA, HA and PCOS)--42 women; Phenotype B (OA and H)--23 women; Phenotype C (OA and PCOS)--20 women; Phenotype D (PCOS and OA)--15 women. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, androstenedione, estradiol (E2) and the Anti-Mullerian Hormone (AMH) are measured during the early follicular phase (day 3-5) of spontaneous menstrual cycle or progestin--induced uterine bleeding.
Record the difference in the values of AMH in the main phenotypes subject of the study. We found different in strength and direction of correlations between the levels of AMH and other hormonal parameters studied.
These data on serum AMH levels in four major phenotypes of PCOS allow its use as an additional diagnostic criterion for diagnosis. Furthermore, differences in serum proven its level at the leading phenotypic expression may serve as a reliable tool to characterize the severity of the syndrome, monitoring and forecasting.
多囊卵巢综合征（PCOS）是育龄女性最常见的内分泌紊乱疾病，也是少排卵/无排卵性不孕的主要原因。根据综合征的表型表达作为诊断标准，PCOS在人群中的发病率为5%-10%。抗苗勒管激素可被定义为一种具有自分泌和旁分泌作用的糖蛋白生长因子。它由卵巢颗粒细胞产生，与卵泡的生长发育有关。关于抗苗勒管激素（AMH）与PCOS之间的关系以及PCOS主要表型中的激素水平的研究结果相互矛盾且数量较少。
比较多囊卵巢综合征主要表型（A、B、C、D）中抗苗勒管激素（AMH）的血清水平。并研究抗苗勒管激素（AMH）血清水平与其他激素参数之间的相关性。
前瞻性比较研究。
本研究在普罗夫迪夫圣乔治大学医院妇产科和普罗夫迪夫圣乔治大学医院内分泌科进行。我们根据美国生殖医学学会（ASRM）-鹿特丹2003年标准，选取了100名年龄在18-35岁之间的多囊卵巢综合征（PCOS）女性。根据表型特征分为四组：A表型（排卵异常、高雄激素血症和PCOS）--42名女性；B表型（排卵异常和高雄激素血症）--23名女性；C表型（排卵异常和PCOS）--20名女性；D表型（PCOS和排卵异常）--15名女性。在自然月经周期的卵泡早期（第3-5天）或孕激素诱导的子宫出血期间，测量血清促黄体生成素（LH）、促卵泡生成素（FSH）、睾酮、雄烯二酮、雌二醇（E2）和抗苗勒管激素（AMH）水平。
记录研究主要表型中AMH值的差异。我们发现AMH水平与其他研究的激素参数之间的相关性在强度和方向上存在差异。
这些关于PCOS四种主要表型中血清AMH水平的数据使其可作为额外的诊断标准。此外，血清水平在主要表型表达中的差异可作为表征综合征严重程度、监测和预测的可靠工具。
