Bentur Yedidia, Lurie Yael, Cahana Alfred, Kovler Nona, Bloom-Krasik Anna, Gurevych Bella, Klein-Schwartz Wendy
Rambam Health Care Campus, affiliated with Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Isr Med Assoc J. 2014 Nov;16(11):686-92.
The Israel National Poison Information Center (IPIC), Rambam Health Care Campus, provides 24 hour telephone consultations in clinical toxicology as well as drug and teratogen information. It participates in research, teaching and regulatory activities, and also provides laboratory services.
To report data on the epidemiology of poisonings and poison exposures in Israel.
We made computerized queries and descriptive analyses of the medical records database of the IPIC during 2012.
A total of 31,519 poison exposure cases were recorded, a 157.6% increase compared with 1995. Children < 6 years of age were involved in 43.1% of cases; 74.0% of calls were made by the public and 23.7% by physicians; 74.8% of exposures were unintentional and 9.1% intentional. Chemicals were involved in 35.8% of all cases (single and multiple substances), pharmaceuticals in 48.8%, bites and stings in 3.8%, and plants and mushrooms in 1.6%. Substances most frequently involved were analgesics, cleaning products and antimicrobials. Clinical severity was moderate/major in 3.4%. Substances most frequently involved in moderate/major exposures were corrosives, insecticides and snake venom. Four fatalities were recorded; all were intentional exposures in adults (corrosive, medications, energy drink).
Poison exposures and poisonings have increased significantly and have contributed substantially to morbidity and mortality in Israel. The IPIC database is a valuable national resource for the collection and monitoring of poisoning exposure cases. It can be used as a real-time surveillance system for the benefit of public health. It is recommended that reporting to the IPIC become mandatory and its activities be adequately supported by national resources.
位于兰巴姆医疗保健校园的以色列国家中毒信息中心（IPIC）提供临床毒理学方面的24小时电话咨询以及药物和致畸物信息。它参与研究、教学和监管活动，还提供实验室服务。
报告以色列中毒和毒物暴露的流行病学数据。
我们对IPIC 2012年的医疗记录数据库进行了计算机查询和描述性分析。
共记录了31519例毒物暴露病例，与1995年相比增加了157.6%。6岁以下儿童占病例的43.1%；74.0%的电话由公众拨打，23.7%由医生拨打；74.8%的暴露是无意的，9.1%是有意的。化学品涉及所有病例的35.8%（单一和多种物质），药物占48.8%，叮咬和蜇伤占3.8%，植物和蘑菇占1.6%。最常涉及的物质是镇痛药、清洁产品和抗菌剂。临床严重程度为中度/重度的占3.4%。中度/重度暴露最常涉及的物质是腐蚀性物质、杀虫剂和蛇毒。记录了4例死亡；均为成人的有意暴露（腐蚀性物质、药物、能量饮料）。
毒物暴露和中毒显著增加，对以色列的发病率和死亡率有重大影响。IPIC数据库是收集和监测中毒暴露病例的宝贵国家资源。它可作为实时监测系统以促进公共卫生。建议向IPIC报告成为强制性要求，并由国家资源充分支持其活动。
