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冠状动脉搭桥术后心肌梗死第三次通用定义的实施:西欧的一项调查研究

Implementation of the third universal definition of myocardial infarction after coronary artery bypass grafting: a survey study in Western Europe.

作者信息

van Beek Dianne E C, van Zaane Bas, Buijsrogge Marc P, van Klei Wilton A

机构信息

Department of Anesthesiology, University Medical Center, Utrecht, The Netherlands (D.C.B., B.Z., W.A.K.).

Department of Cardiothoracic Surgery, University Medical Center, Utrecht, The Netherlands (M.P.B.).

出版信息

J Am Heart Assoc. 2015 Jan 5;4(1):e001401. doi: 10.1161/JAHA.114.001401.

Abstract

BACKGROUND

Diagnosing a postoperative myocardial infarction in patients undergoing coronary artery bypass grafting is challenging, as the normally used criteria are more difficult to interpret. The rate of implementation of the consensus-based new diagnostic criteria for postoperative myocardial infarction proposed by the third universal definition of myocardial infarction is unknown. Therefore, the primary objective of this study was to address the implementation of the third universal definition of postoperative myocardial infarction following coronary artery bypass grafting.

METHODS AND RESULTS

We conducted a web-based survey by sending 4 waves of invitations via e-mail to cardiothoracic surgeons in 12 Western European countries. Of the 302 participating cardiothoracic specialists, from 182 different centers, 213 (71%) were aware that troponin is the preferred biomarker and 112 (37%) knew that using a cut-off level of >10 times the 99th percentile is recommended. Overall, 90 (30%) participants (strongly) agreed with implementation of this cut-off level in their clinical practice. Troponin was used in clinical practice by 149 (49%) of the participants. In total, 117 (89%) of the 131 participants with a local guideline confirmed ECG changes as a diagnostic criterion in that guideline. ST segmental changes (75, 64%) were used more often for diagnosing postoperative myocardial infarction than Q waves (64, 55%) or new left bundle branch blocks (34, 29%).

CONCLUSIONS

Cardiac biomarkers and ECG changes were not used in concordance with the third universal definition, and only a minority had a positive attitude toward implementation of the proposed cut-off level for troponin in their clinical practice.

摘要

背景

诊断接受冠状动脉旁路移植术患者的术后心肌梗死具有挑战性,因为常用标准更难解读。心肌梗死第三次全球定义提出的基于共识的术后心肌梗死新诊断标准的实施率尚不清楚。因此,本研究的主要目的是探讨冠状动脉旁路移植术后心肌梗死第三次全球定义的实施情况。

方法与结果

我们通过电子邮件分4轮邀请12个西欧国家的心胸外科医生进行了一项基于网络的调查。在302名参与调查的心胸外科专家中,来自182个不同中心,213名(71%)知道肌钙蛋白是首选生物标志物,112名(37%)知道建议使用高于第99百分位数10倍的临界值。总体而言,90名(30%)参与者(强烈)同意在其临床实践中实施该临界值。149名(49%)参与者在临床实践中使用了肌钙蛋白。在131名有当地指南的参与者中,共有117名(89%)确认心电图变化是该指南中的诊断标准。ST段变化(75名,64%)比Q波(64名,55%)或新的左束支传导阻滞(34名,29%)更常用于诊断术后心肌梗死。

结论

心脏生物标志物和心电图变化的使用与第三次全球定义不一致,只有少数人对在临床实践中实施建议的肌钙蛋白临界值持积极态度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6c2/4330065/976c1d0f7d5f/jah3-4-e001401-g1.jpg

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