Chan J K, Tsui W M, Tung S Y, Ching R C
Institute of Pathology, Queen Elizabeth Hospital, Hong Kong.
Am J Clin Pathol. 1989 Dec;92(6):825-30. doi: 10.1093/ajcp/92.6.825.
A 33-year-old woman who presented with vaginal bleeding was diagnosed to have neuroendocrine small cell carcinoma based on cervical smear and biopsy. Hysterectomy was performed, and a tumor measuring 5.5 X 2 mm was found at the squamocolumnar junction of the uterine cervix. In the immediate vicinity of the tumor, there was proliferation of cytologically benign endocrine cells in the normal endocervical glands and in the glands showing intraepithelial glandular neoplasia. Both the hyperplastic endocrine cells and the invasive tumor cells showed argyrophilia and immunostaining for neuron-specific enolase, neurofilament, and chromogranin. The topographical relationship suggests that endocrine cell hyperplasia may represent a precursor of neuroendocrine carcinoma of the cervix.
一名33岁出现阴道出血的女性，经宫颈涂片和活检被诊断为神经内分泌小细胞癌。进行了子宫切除术，在子宫颈鳞柱交界处发现一个大小为5.5×2毫米的肿瘤。在肿瘤紧邻区域，正常宫颈腺体内以及显示上皮内腺体瘤变的腺体内，细胞学上良性的内分泌细胞出现增殖。增生的内分泌细胞和侵袭性肿瘤细胞均显示嗜银性，并对神经元特异性烯醇化酶、神经丝和嗜铬粒蛋白呈免疫染色阳性。这种局部解剖关系提示，内分泌细胞增生可能是宫颈神经内分泌癌的前驱病变。
