Rondón Lusliany Josefina, Marcano Eunice, Rodríguez Fátima, del Castillo Jesús Rafael
Instituto Venezolano de Investigaciones Científicas (IVIC), Centro de Biofísica y Bioquímica, Laboratorio de Fisiología Molecular, Altos de Pipe, Estado Miranda, Venezuela.
IVIC, Centro de Química, Laboratorio de Química Analítica, Altos de Pipe, Estado Miranda, Venezuela.
Magnes Res. 2014 Jul-Sep;27(3):113-30. doi: 10.1684/mrh.2014.0368.
The renin-angiotensin system is critically involved in regulating arterial blood pressure (BP). Inappropriate angiotensin type-1 receptor activation by angiotensin-II (Ang-II) is related to increased arterial BP. Mg has a role in BP; it can affect cardiac electrical activity, myocardial contractility, and vascular tone. To evaluate the relationship between high BP induced by a high sodium (Na) diet and Mg, and other mineral balances, two experimental rat models of salt-sensitive, induced-hypertension were used: Ang-II infused and Dahl salt-sensitive (SS) rats. We found that: 1) Ang-II infusion progressively increased BP, which was accompanied by hypomagnesuria and signs of secondary hyperaldosteronism; 2) an additive effect between Ang-II and a high Na load may have an effect on strontium (Sr), zinc (Zn) and copper (Cu) balances; 3) Dahl SS rats fed a high Na diet had a slow pressor response, accompanied by altered Mg, Na, potassium (K), and phosphate (P) balances; and 4) losartan prevented BP increases induced by Ang II-NaCl, but did not modify mineral balances. In Dahl SS rats, losartan attenuated high BP and ameliorated magnesemia, Na and K balances. Mg metabolism maybe considered a possible defect in this strain of rat that may contribute to hypertension.
肾素-血管紧张素系统在调节动脉血压（BP）方面起着关键作用。血管紧张素-II（Ang-II）对1型血管紧张素受体的不适当激活与动脉血压升高有关。镁在血压调节中发挥作用；它可以影响心脏电活动、心肌收缩力和血管张力。为了评估高钠（Na）饮食诱导的高血压与镁以及其他矿物质平衡之间的关系，我们使用了两种盐敏感性诱导高血压的实验大鼠模型：Ang-II灌注大鼠和Dahl盐敏感（SS）大鼠。我们发现：1）Ang-II灌注使血压逐渐升高，同时伴有低镁尿症和继发性醛固酮增多症的迹象；2）Ang-II与高钠负荷之间的叠加效应可能对锶（Sr）、锌（Zn）和铜（Cu）平衡产生影响；3）喂食高钠饮食的Dahl SS大鼠升压反应缓慢，同时伴有镁、钠、钾（K）和磷酸盐（P）平衡的改变；4）氯沙坦可预防Ang II-氯化钠诱导的血压升高，但不会改变矿物质平衡。在Dahl SS大鼠中，氯沙坦可减轻高血压并改善血镁、钠和钾平衡。镁代谢可能被认为是该品系大鼠中可能导致高血压的一个潜在缺陷。
