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2014 年结直肠癌治疗进展:一线治疗和维持治疗的定义。

Colorectal cancer in 2014: progress in defining first-line and maintenance therapies.

机构信息

Division of Medical Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

出版信息

Nat Rev Clin Oncol. 2015 Feb;12(2):73-4. doi: 10.1038/nrclinonc.2014.233. Epub 2015 Jan 6.

DOI:10.1038/nrclinonc.2014.233
PMID:25560533
Abstract

The results of several clinical trials in metastatic colorectal cancer presented in 2014 will influence clinical practice. These findings include definitive data from phase III trials comparing bevacizumab and cetuximab-based therapy in the first-line, studies elucidating the value of maintenance therapy after induction treatment, and data on new agents in this disease.

摘要

2014 年报告的几项转移性结直肠癌的临床试验结果将影响临床实践。这些发现包括比较贝伐单抗和西妥昔单抗一线治疗的 III 期临床试验的明确数据、阐明诱导治疗后维持治疗价值的研究,以及该疾病新药物的数据。

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Lancet Oncol. 2014 Sep;15(10):1065-75. doi: 10.1016/S1470-2045(14)70330-4. Epub 2014 Jul 31.
2
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial.regorafenib 单药治疗既往治疗的转移性结直肠癌(CORRECT):一项国际、多中心、随机、安慰剂对照、3 期临床试验。
Lancet. 2013 Jan 26;381(9863):303-12. doi: 10.1016/S0140-6736(12)61900-X. Epub 2012 Nov 22.
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