白细胞介素1β对促甲状腺激素释放激素刺激的催乳素分泌和磷酸肌醇代谢的抑制作用。

Interleukin 1 beta inhibition of TRH-stimulated prolactin secretion and phosphoinositides metabolism.

作者信息

Schettini G, Landolfi E, Grimaldi M, Meucci O, Postiglione A, Florio T, Ventra C

机构信息

Institute of Pharmacology, II School of Medicine, University of Naples, Italy.

出版信息

Biochem Biophys Res Commun. 1989 Nov 30;165(1):496-505. doi: 10.1016/0006-291x(89)91097-8.

DOI:10.1016/0006-291x(89)91097-8

PMID:2556147

Abstract

The effect of interleukin 1 beta on prolactin secretion and on phosphoinositide turnover in anterior pituitary cells was evaluated. Interleukin 1 beta significantly inhibited TRH-stimulated prolactin secretion assessed by the reverse hemolytic plaque assay. In particular, the cytokine reduced the percentage of plaque forming cells, the plaque mean area, the large plaques percentage. TRH-stimulated inositol phosphate production was also significantly inhibited by interleukin 1 beta. This study shows that interleukin 1 beta reduces TRH-induced prolactin secretion through a direct action on pituitary cell, and attenuates the TRH-stimulated phosphoinositide breakdown. This latter effect may suggest that the reduced lactotropes sensitivity to TRH action may be partially due to interleukin 1 beta inhibition of phosphatidylinositol breakdown.

摘要

评估了白细胞介素1β对垂体前叶细胞催乳素分泌及磷酸肌醇代谢的影响。通过反向溶血空斑试验评估，白细胞介素1β显著抑制促甲状腺激素释放激素（TRH）刺激的催乳素分泌。具体而言，该细胞因子降低了空斑形成细胞的百分比、空斑平均面积及大空斑百分比。白细胞介素1β也显著抑制TRH刺激的肌醇磷酸生成。本研究表明，白细胞介素1β通过对垂体细胞的直接作用降低TRH诱导的催乳素分泌，并减弱TRH刺激的磷酸肌醇分解。后一种效应可能提示，促乳素细胞对TRH作用的敏感性降低可能部分归因于白细胞介素1β对磷脂酰肌醇分解的抑制。