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新辅助化疗后保留胃网膜右动脉冠状动脉搭桥术治疗进展期胃癌的根治性切除术:病例报告

Curative Resection Following Neoadjuvant Chemotherapy for Advanced Gastric Cancer With Preservation of a Right Gastroepiploic Artery Coronary Artery Bypass Graft: A Case Report.

作者信息

Suzuki Masaki, Ogata Kyoichi, Kogure Norimichi, Kimura Akiharu, Toyomasu Yoshitaka, Ohno Tetsuro, Mochiki Erito, Kuwano Hiroyuki

机构信息

1 Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

2 Department of Surgery, Chichibu Hospital, Chichibu, Saitama, Japan.

出版信息

Int Surg. 2015 Jun;100(6):1138-43. doi: 10.9738/INTSURG-D-14-00156.1. Epub 2015 Jan 6.

Abstract

Recently, the right gastroepiploic artery (RGEA) has been used in coronary artery bypass graft (CABG) as an alternative arterial graft. Because of the improvement of prognosis after CABG, malignant diseases are more common in older patients. However, there is a serious problem in patients with gastric cancer after CABG with RGEA graft. In these patients, an interruption of coronary blood supply through the RGEA may cause a life-threatening myocardial ischemia. Therefore, an appropriate strategy is very important to avoid risk while retaining the curability of the operation. We herein describe a 76-year-old Japanese man with advanced gastric cancer who underwent CABG using the RGEA. Abdominal computed tomography (CT) showed #6 lymph nodes (sub-pyloric lymph nodes) metastases surrounding the RGEA. We concluded that curative resection was impossible while preserving the RGEA and started combination chemotherapy using S-1 and cisplatin. After 2 courses of that, #6 lymph nodes were reduced extremely. Thereafter the patient underwent distal gastrectomy with regional lymph node dissection around the RGEA without excision of the RGEA. Histologically, there were no metastases in #6 lymph nodes. Neoadjuvant chemotherapy may be effective for preserving the RGEA graft in a patient with advanced gastric cancer after CABG.

摘要

最近,胃网膜右动脉(RGEA)已被用作冠状动脉旁路移植术(CABG)中的替代动脉移植物。由于CABG后预后的改善,恶性疾病在老年患者中更为常见。然而,接受RGEA移植物CABG的胃癌患者存在一个严重问题。在这些患者中,通过RGEA的冠状动脉血液供应中断可能导致危及生命的心肌缺血。因此,在保持手术可治愈性的同时避免风险的适当策略非常重要。我们在此描述一名76岁的日本晚期胃癌男性患者,他接受了使用RGEA的CABG。腹部计算机断层扫描(CT)显示RGEA周围有#6淋巴结(幽门下淋巴结)转移。我们得出结论,在保留RGEA的情况下无法进行根治性切除,并开始使用S-1和顺铂进行联合化疗。经过2个疗程后,#6淋巴结显著缩小。此后,患者接受了RGEA周围区域淋巴结清扫的远端胃切除术,但未切除RGEA。组织学检查显示,#6淋巴结无转移。新辅助化疗对于保留CABG后晚期胃癌患者的RGEA移植物可能有效。

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