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本文引用的文献

1
Meta-analysis of preclinical studies of mesenchymal stromal cells for ischemic stroke.间充质基质细胞治疗缺血性脑卒中的临床前研究的荟萃分析。
Neurology. 2014 Apr 8;82(14):1277-86. doi: 10.1212/WNL.0000000000000278. Epub 2014 Mar 7.
2
Human bone marrow mesenchymal stem/stromal cells produce efficient localization in the brain and enhanced angiogenesis after intra-arterial delivery in rats with cerebral ischemia, but this is not translated to behavioral recovery.在大脑缺血的大鼠中，经动脉递送后，人骨髓间充质干/基质细胞在脑内产生高效定位并增强血管生成，但这并未转化为行为恢复。
Behav Brain Res. 2014 Feb 1;259:50-9. doi: 10.1016/j.bbr.2013.10.030. Epub 2013 Oct 29.
3
Intra-arterial infusion of human bone marrow-derived mesenchymal stem cells results in transient localization in the brain after cerebral ischemia in rats.经动脉输注人骨髓间充质干细胞可导致脑缺血大鼠脑内短暂定位。
Exp Neurol. 2013 Jan;239:158-62. doi: 10.1016/j.expneurol.2012.09.018. Epub 2012 Oct 8.
4
Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats.比派利啶可降低大鼠大脑中动脉闭塞后丘脑内的 Aβ 和钙水平。
J Cell Mol Med. 2012 Nov;16(11):2754-67. doi: 10.1111/j.1582-4934.2012.01599.x.
5
Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus.大鼠局灶性脑缺血会改变丘脑淀粉样前体蛋白（APP）的加工过程以及β淀粉样肽（Aβ）降解酶的表达。
Neurobiol Dis. 2009 Jul;35(1):103-13. doi: 10.1016/j.nbd.2009.04.009. Epub 2009 May 5.
6
Challenges and possibilities of intravascular cell therapy in stroke.中风血管内细胞治疗的挑战与可能性
Acta Neurobiol Exp (Wars). 2009;69(1):1-11. doi: 10.55782/ane-2009-1724.
7
Coaccumulation of calcium and beta-amyloid in the thalamus after transient middle cerebral artery occlusion in rats.大鼠大脑中动脉短暂闭塞后丘脑钙与β-淀粉样蛋白的共蓄积
J Cereb Blood Flow Metab. 2008 Feb;28(2):263-8. doi: 10.1038/sj.jcbfm.9600529. Epub 2007 Jul 25.
8
Long-term functional outcome following transient middle cerebral artery occlusion in the rat: correlation between brain damage and behavioral impairment.大鼠大脑中动脉短暂闭塞后的长期功能转归：脑损伤与行为障碍之间的相关性。
Behav Neurosci. 2006 Dec;120(6):1285-98. doi: 10.1037/0735-7044.120.6.1285.
9
Beta-amyloid aggregation in human brains with cerebrovascular lesions.患有脑血管病变的人类大脑中的β-淀粉样蛋白聚集。
Stroke. 2006 Dec;37(12):2940-5. doi: 10.1161/01.STR.0000248777.44128.93. Epub 2006 Nov 9.
10
Human umbilical cord blood cells do not improve sensorimotor or cognitive outcome following transient middle cerebral artery occlusion in rats.在大鼠短暂大脑中动脉闭塞后，人脐带血细胞不能改善感觉运动或认知结果。
Brain Res. 2006 Dec 6;1123(1):207-15. doi: 10.1016/j.brainres.2006.09.056. Epub 2006 Oct 30.

大鼠中风模型中的意外并发症：亚急性动脉内注射人骨髓间充质干细胞加剧丘脑继发性病理改变

Unexpected complication in a rat stroke model: exacerbation of secondary pathology in the thalamus by subacute intraarterial administration of human bone marrow-derived mesenchymal stem cells.

作者信息

Mitkari Bhimashankar, Kerkelä Erja, Nystedt Johanna, Korhonen Matti, Jolkkonen Jukka

机构信息

Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland.

Finnish Red Cross Blood Service, Research and Cell Therapy Services, Helsinki, Finland.

出版信息

J Cereb Blood Flow Metab. 2015 Mar;35(3):363-6. doi: 10.1038/jcbfm.2014.235. Epub 2015 Jan 7.

DOI:10.1038/jcbfm.2014.235
PMID:25564231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4348397/
Abstract

This study examined whether human bone marrow mesenchymal stromal/stem cells (BMMSCs) could alleviate the secondary pathology in the thalamus after middle cerebral artery occlusion (MCAO) in rats. Atypical accumulation of both amyloid-β (Aβ) and calcium in the thalamus was significantly higher in rats receiving the BMMSCs infusion 48 hours after MCAO as compared with the vehicle MCAO group. The elevated Aβ/calcium accumulation correlated with the level of impaired sensorimotor function. Although secondary pathology in the thalamus seems to be rodent specific, it needs to be taken into account because it may impair long-term behavioral recovery and negate therapeutic treatment effects.

摘要

本研究检测了人骨髓间充质基质/干细胞（BMMSCs）能否减轻大鼠大脑中动脉闭塞（MCAO）后丘脑的继发性病理改变。与MCAO模型组相比，MCAO术后48小时接受BMMSCs输注的大鼠丘脑内淀粉样β蛋白（Aβ）和钙的异常蓄积显著更高。Aβ/钙蓄积的升高与感觉运动功能受损程度相关。尽管丘脑的继发性病理改变似乎具有啮齿类动物特异性，但仍需加以考虑，因为它可能会损害长期行为恢复并抵消治疗效果。