功能失调的菌群：梭状芽孢杆菌和次级胆汁酸可抑制艰难梭菌的生长。
Dysfunctional families: Clostridium scindens and secondary bile acids inhibit the growth of Clostridium difficile.
作者信息
Greathouse K Leigh, Harris Curtis C, Bultman Scott J
机构信息
Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
出版信息
Cell Metab. 2015 Jan 6;21(1):9-10. doi: 10.1016/j.cmet.2014.12.016.
Abstract
C. difficile infection is a deadly disease that is influenced by the microbiome. In a recent article in Nature, Buffie et al. (2014) demonstrate that the ability of C. scindens to synthesize secondary bile acids is crucial to providing resistance to C. difficile infection.
摘要
艰难梭菌感染是一种受微生物群影响的致命疾病。在《自然》杂志最近的一篇文章中，布菲等人（2014年）证明，斯氏梭菌合成次级胆汁酸的能力对于提供对艰难梭菌感染的抵抗力至关重要。
相似文献
1
Dysfunctional families: Clostridium scindens and secondary bile acids inhibit the growth of Clostridium difficile.功能失调的菌群：梭状芽孢杆菌和次级胆汁酸可抑制艰难梭菌的生长。
Cell Metab. 2015 Jan 6;21(1):9-10. doi: 10.1016/j.cmet.2014.12.016.
2
Microbial bile acid metabolic clusters: the bouncers at the bar.微生物胆汁酸代谢簇：酒吧的门卫。
Cell Host Microbe. 2014 Nov 12;16(5):551-2. doi: 10.1016/j.chom.2014.10.015.
3
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile.精准微生物群重建可恢复胆汁酸介导的对艰难梭菌的抗性。
Nature. 2015 Jan 8;517(7533):205-8. doi: 10.1038/nature13828. Epub 2014 Oct 22.
4
Infection: microbiota reconstitution for resistance to Clostridium difficile infection--fight fire with fire?感染：通过重建微生物群来抵抗艰难梭菌感染——以毒攻毒？
Nat Rev Gastroenterol Hepatol. 2015 Jan;12(1):4. doi: 10.1038/nrgastro.2014.194. Epub 2014 Nov 11.
5
Functional Intestinal Bile Acid 7α-Dehydroxylation by Associated with Protection from Infection in a Gnotobiotic Mouse Model.在悉生小鼠模型中，功能性肠道胆汁酸7α-脱羟基作用与抵御感染相关。
Front Cell Infect Microbiol. 2016 Dec 20;6:191. doi: 10.3389/fcimb.2016.00191. eCollection 2016.
6
Strain-Dependent Inhibition of Clostridioides difficile by Commensal Carrying the Bile Acid-Inducible () Operon.依赖于应变的共生菌携带胆汁酸诱导（）操纵子对艰难梭菌的抑制作用。
J Bacteriol. 2020 May 11;202(11). doi: 10.1128/JB.00039-20.
7
Systematic discovery of probiotics.益生菌的系统性发现。
Nat Biotechnol. 2015 Jan;33(1):47-9. doi: 10.1038/nbt.3111.
8
Role of the intestinal microbiota in resistance to colonization by Clostridium difficile.肠道微生物群在抵抗艰难梭菌定植中的作用。
Gastroenterology. 2014 May;146(6):1547-53. doi: 10.1053/j.gastro.2014.01.059. Epub 2014 Feb 4.
9
Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection.微生物群移植可恢复复发性艰难梭菌感染患者的正常粪便胆汁酸组成。
Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15;306(4):G310-9. doi: 10.1152/ajpgi.00282.2013. Epub 2013 Nov 27.
10
Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids.胆汁酸 7α-脱羟肠道细菌分泌的抗生素可抑制艰难梭菌：次级胆汁酸的作用。
Cell Chem Biol. 2019 Jan 17;26(1):27-34.e4. doi: 10.1016/j.chembiol.2018.10.003. Epub 2018 Oct 25.
引用本文的文献
1
A designed synthetic microbiota provides insight to community function in Clostridioides difficile resistance.一种设计的合成微生物群有助于深入了解艰难梭菌抗性中的群落功能。
Cell Host Microbe. 2025 Mar 12;33(3):373-387.e9. doi: 10.1016/j.chom.2025.02.007. Epub 2025 Mar 3.
2
Bioengineered Probiotics for Clostridioides difficile Infection: An Overview of the Challenges and Potential for This New Treatment Approach.用于艰难梭菌感染的生物工程益生菌：这种新治疗方法的挑战与潜力概述
Probiotics Antimicrob Proteins. 2025 Apr;17(2):763-780. doi: 10.1007/s12602-024-10398-x. Epub 2024 Nov 12.
3
Fecal Microbiota Transplantation for Recurrent Infections in a Cystic Fibrosis Child Previously Screen Positive, Inconclusive Diagnosis (CFSPID): A Case Report.粪菌移植治疗一名先前筛查呈阳性、诊断不确定（CFSPID）的囊性纤维化儿童复发性感染：病例报告
Microorganisms. 2024 Oct 12;12(10):2059. doi: 10.3390/microorganisms12102059.
4
Gut microbiome therapy: fecal microbiota transplantation vs live biotherapeutic products.肠道微生物组治疗：粪便微生物群移植与活菌治疗产品。
Gut Microbes. 2024 Jan-Dec;16(1):2412376. doi: 10.1080/19490976.2024.2412376. Epub 2024 Oct 8.
5
Interplay between Bile Acids and Intestinal Microbiota: Regulatory Mechanisms and Therapeutic Potential for Infections.胆汁酸与肠道微生物群的相互作用：感染的调节机制与治疗潜力
Pathogens. 2024 Aug 20;13(8):702. doi: 10.3390/pathogens13080702.
6
co-culture of with primary human colonic epithelium protects the epithelium against .与原代人结肠上皮细胞共培养可保护上皮细胞免受……（原文此处“against”后内容缺失）
Front Bioeng Biotechnol. 2024 Apr 12;12:1382389. doi: 10.3389/fbioe.2024.1382389. eCollection 2024.
7
infection is associated with differences in transcriptionally active microbial communities.感染与转录活跃的微生物群落差异有关。
Front Microbiol. 2024 Apr 12;15:1398018. doi: 10.3389/fmicb.2024.1398018. eCollection 2024.
8
The Human Gut Microbiota: A Dynamic Biologic Factory.人类肠道微生物群：一个动态的生物工厂。
Adv Biochem Eng Biotechnol. 2025;189:91-106. doi: 10.1007/10_2023_243.
9
Chronic Arsenic Exposure Perturbs Gut Microbiota and Bile Acid Homeostasis in Mice.慢性砷暴露扰乱了小鼠的肠道微生物群和胆汁酸稳态。
Chem Res Toxicol. 2023 Jul 17;36(7):1037-1043. doi: 10.1021/acs.chemrestox.2c00410. Epub 2023 Jun 9.
10
Traumatic brain injury alters the gut-derived serotonergic system and associated peripheral organs.创伤性脑损伤改变了肠道来源的 5-羟色胺能系统和相关的外周器官。
Biochim Biophys Acta Mol Basis Dis. 2022 Nov 1;1868(11):166491. doi: 10.1016/j.bbadis.2022.166491. Epub 2022 Jul 25.
本文引用的文献
1
Microbiome data distinguish patients with Clostridium difficile infection and non-C. difficile-associated diarrhea from healthy controls.微生物组数据可将艰难梭菌感染患者、非艰难梭菌相关性腹泻患者与健康对照区分开来。
mBio. 2014 May 6;5(3):e01021-14. doi: 10.1128/mBio.01021-14.
2
Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection.抗生素引起的小鼠肠道微生物群和代谢组变化会增加其对艰难梭菌感染的易感性。
Nat Commun. 2014;5:3114. doi: 10.1038/ncomms4114.
3
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.共生微生物衍生的丁酸盐诱导结肠调节性 T 细胞的分化。
Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
4
Bile acid recognition by the Clostridium difficile germinant receptor, CspC, is important for establishing infection.艰难梭菌发芽受体 CspC 对胆汁酸的识别对于建立感染很重要。
PLoS Pathog. 2013 May;9(5):e1003356. doi: 10.1371/journal.ppat.1003356. Epub 2013 May 9.
5
Relationship of symptom duration and fecal bacteriotherapy in Clostridium difficile infection-pooled data analysis and a systematic review.艰难梭菌感染中症状持续时间与粪便细菌疗法的关系——汇总数据分析与系统评价
Scand J Gastroenterol. 2013 Mar;48(3):266-73. doi: 10.3109/00365521.2012.743585. Epub 2012 Nov 19.
6
Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice.用简单、明确的细菌疗法靶向修复肠道微生物群可解决小鼠复发性艰难梭菌病。
PLoS Pathog. 2012;8(10):e1002995. doi: 10.1371/journal.ppat.1002995. Epub 2012 Oct 25.
7
Clostridium difficile infection: the scope of the problem.艰难梭菌感染：问题的范围。
J Hosp Med. 2012 Mar;7 Suppl 3:S1-4. doi: 10.1002/jhm.1916.
8
Isolation and characterization of a bile acid inducible 7alpha-dehydroxylating operon in Clostridium hylemonae TN271.从 Clostridium hylemonae TN271 中分离并鉴定胆汁酸诱导的 7α-脱羟化酶操纵子。
Anaerobe. 2010 Apr;16(2):137-46. doi: 10.1016/j.anaerobe.2009.05.004. Epub 2009 May 21.
9
Bile salt biotransformations by human intestinal bacteria.人类肠道细菌对胆汁盐的生物转化
J Lipid Res. 2006 Feb;47(2):241-59. doi: 10.1194/jlr.R500013-JLR200. Epub 2005 Nov 18.
Zotero 插件