Enhancing cognition before clinical symptoms of dementia.
作者信息
Franco Rafael
机构信息
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona Barcelona, Spain ; CIBERNED: Centro de Investigación en Red sobre Enfermedades Neurodegenerativas, Instituto de Investigación Carlos III Madrid, Spain.
出版信息
Front Syst Neurosci. 2014 Dec 16;8:240. doi: 10.3389/fnsys.2014.00240. eCollection 2014.
Abstract
摘要
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本文引用的文献
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Phosphodiesterase inhibition in cognitive decline.认知衰退中的磷酸二酯酶抑制作用。
J Alzheimers Dis. 2014;42 Suppl 4:S561-73. doi: 10.3233/JAD-141341.
2
Successful therapies for Alzheimer's disease: why so many in animal models and none in humans?阿尔茨海默病的成功治疗方法：为何在动物模型中有如此多的方法，而在人类中却没有？
Front Pharmacol. 2014 Jun 25;5:146. doi: 10.3389/fphar.2014.00146. eCollection 2014.
3
Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice.静脉内给予抗坏血酸可改善中年 APP/PSEN1 转基因和野生型小鼠的空间记忆。
Behav Brain Res. 2014 May 1;264:34-42. doi: 10.1016/j.bbr.2014.01.044. Epub 2014 Feb 5.
4
Effects of daily low-dose treatment with phosphodiesterase type 5 inhibitor on cognition, depression, somatization and erectile function in patients with erectile dysfunction: a double-blind, placebo-controlled study.每日低剂量磷酸二酯酶 5 抑制剂治疗对勃起功能障碍患者认知功能、抑郁、躯体化和勃起功能的影响：一项双盲、安慰剂对照研究。
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5
Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in APP/PS1 transgenic mice.磷酸二酯酶-5 抑制剂西地那非可预防神经炎症、降低β-淀粉样蛋白水平并改善 APP/PS1 转基因小鼠的认知功能。
Behav Brain Res. 2013 Aug 1;250:230-7. doi: 10.1016/j.bbr.2013.05.017. Epub 2013 May 16.
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Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model.苯丁酸钠是一种多效药物，具有神经保护作用，并能逆转一种常用的小鼠模型的阿尔茨海默病样表型。
Curr Pharm Des. 2013;19(28):5076-84. doi: 10.2174/1381612811319280006.
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The effects of the phosphodiesterase type 5 inhibitor vardenafil on cognitive performance in healthy adults: a behavioral-electroencephalography study.5 型磷酸二酯酶抑制剂伐地那非对健康成年人认知表现的影响：一项行为-脑电图研究。
J Psychopharmacol. 2013 Jul;27(7):600-8. doi: 10.1177/0269881113477747. Epub 2013 Feb 20.
8
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Neuropharmacology. 2013 Jan;64:114-23. doi: 10.1016/j.neuropharm.2012.06.052. Epub 2012 Jul 7.
9
Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease.定义 4-苯基丁酸的作用机制，开发用于治疗阿尔茨海默病的基于小分子的疗法。
Curr Med Chem. 2011;18(36):5545-53. doi: 10.2174/092986711798347315.
10
Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease.西地那非可恢复认知功能，而不影响阿尔茨海默病小鼠模型中的β-淀粉样蛋白负担。
Br J Pharmacol. 2011 Dec;164(8):2029-41. doi: 10.1111/j.1476-5381.2011.01517.x.
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