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[中国HIV-1基因型的分布：一项系统评价]

[Distribution of HIV-1 genotypes in China: a systematic review].

作者信息

Su Yingying, Liu Huixin, Wu Jing, Zhu Lin, Wang Ning

机构信息

National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Email:

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2014 Oct;35(10):1164-8.

PMID:25567027

Abstract

OBJECTIVE

To provide information on the geographical distribution of HIV-1 genotypes and subtypes in the population of China.

METHODS

A comprehensive search was carried out in China Hospital Knowledge Database (CHKD), Wanfang (Chinese), CBMDisc and PubMed databases to identify all studies published related to HIV-1 genotypes in China. All studies were grouped according to the sites, period and objects for analyzing the distribution of HIV genotypes.

RESULTS

A total of 175 studies were included in this Meta-analysis, which contained 285 records. We found that the predominate genotypes in China were B' subtype, CRF01_AE, CRF07_BC and CRF08_BC, but the subtype distribution of HIV-1 was different in the western and southern parts of the country. CRF01_AE had a significant increase while subtype B' showed a decrease. There were various HIV-1 subtypes among individuals who acquired HIV through sexual contacts and CRF01_AE was most commonly identified in this group of people.

CONCLUSION

The distribution of HIV-1 genotypes in Chinese people significantly changed, together with high complexity of the HIV-1 epidemics noticed in China.

摘要

目的

提供中国人群中HIV-1基因型和亚型的地理分布信息。

方法

在中国医院知识数据库（CHKD）、万方（中文）、中国生物医学文献数据库和PubMed数据库中进行全面检索，以识别在中国发表的所有与HIV-1基因型相关的研究。所有研究根据地点、时期和对象进行分组，以分析HIV基因型的分布。

结果

本Meta分析共纳入175项研究，包含285条记录。我们发现，中国主要的基因型为B'亚型、CRF01_AE、CRF07_BC和CRF08_BC，但HIV-1的亚型分布在该国西部和南部有所不同。CRF01_AE显著增加，而B'亚型减少。通过性接触感染HIV的个体中存在多种HIV-1亚型，CRF01_AE在这组人群中最为常见。