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通过八聚精氨酸共轭的全 O-甲基-β-环糊精实现阴离子卟啉的超分子细胞内递送。

Supramolecular intracellular delivery of an anionic porphyrin by octaarginine-conjugated per-O-methyl-β-cyclodextrin.

作者信息

Kitagishi Hiroaki, Chai Fumihiko, Negi Shigeru, Sugiura Yukio, Kano Koji

机构信息

Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321, Japan.

出版信息

Chem Commun (Camb). 2015 Feb 11;51(12):2421-4. doi: 10.1039/c4cc09042j.

DOI:10.1039/c4cc09042j
PMID:25567704
Abstract

A convenient and efficient method for intracellular delivery of a water-soluble anionic porphyrin has been developed by utilizing its supramolecular interaction with per-O-methyl-β-cyclodextrin bearing an octaarginine chain as a cell-penetrating peptide.

摘要

通过利用水溶性阴离子卟啉与带有八聚精氨酸链作为细胞穿透肽的全-O-甲基-β-环糊精之间的超分子相互作用，已开发出一种便捷高效的细胞内递送该水溶性阴离子卟啉的方法。

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