Sotirova Tatjana, Stojanovic Aleksandar, Genadieva-Stavric Sonja, Krstevska Svetlana, Spasovski Dejan, Balkanov Trajan
University Clinic of Hematology, Ss Cyril and Methodius University, Skopje, Macedonia.
University Clinic for Rheumatology, Ss Cyril and Methodius University, Skopje, Macedonia.
Mater Sociomed. 2014 Oct;26(5):292-6. doi: 10.5455/msm.2014.26.292-296. Epub 2014 Oct 29.
Accurate prediction of a patient's prognosis is useful to define the risk posed by the disease. Age, gender, peripheral blood cytopenia, proportion of bone marrow (BM) blasts, performance status, comorbidities, transfusion dependence, specific karyotype abnormalities and molecular biomarkers can refine the prediction of prognosis in MDS.
to assess the influence of the some prognostic factors like age, gender, cytopenia, BM blast percentage, transfusion dependence, ferritin, hemoglobin (Hb), lactate dehydrogenase (LDH), albumin and specific karyotype abnormalities in myelodysplastic syndromes on overall survival (OS).
we retrospectively analyzed the cohort of 108 patients diagnosed between 1.1.2011 and 31.12.2013 at the University Clinic of Hematology, Ss Cyril and Methodius University, Skopje, Macedonia. They were evaluated for clinical and hematologic features at diagnosis and at leukemic transformation.
in the study group 62 were man and 46 women. Male to female ratio was 1.35 to 1. The differences in OS between men and women were significant (p = .03015). The mean age at diagnosis was 66,6 years. According to the age OS was 16,4 months. FAB subtypes influenced OS significantly (p = .03015). OS inversely correlated with BM blast percentage (p= .02327). Cytopenia had no impact on OS (p=.33755). Hb as a whole and groups with different levels of Hb had no influence on OS (p = .12142) and (p= .07535), respectively. The group with ferritin <500 µg/L had better OS (p=.04720). Transfusion dependence, LDH and albumin had no impact on OS. Leukemic transformation was noticed in 10 (9,3%) patients. Mortality was 36,1%.
gender, FAB subtypes, BM blast percentage and the serum levels of ferritin had an influence on OS, while age, hemoglobin level, transfusion dependence, LDH and albumin had no impact on OS.
准确预测患者的预后有助于明确疾病所带来的风险。年龄、性别、外周血细胞减少、骨髓原始细胞比例、体能状态、合并症、输血依赖、特定核型异常以及分子生物标志物能够优化骨髓增生异常综合征（MDS）预后的预测。
评估年龄、性别、血细胞减少、骨髓原始细胞百分比、输血依赖、铁蛋白、血红蛋白（Hb）、乳酸脱氢酶（LDH）、白蛋白以及特定核型异常等一些预后因素对骨髓增生异常综合征总生存期（OS）的影响。
我们回顾性分析了2011年1月1日至2013年12月31日期间在马其顿斯科普里圣西里尔和美多迪乌斯大学血液学大学诊所诊断的108例患者队列。对他们在诊断时以及白血病转化时的临床和血液学特征进行了评估。
研究组中男性62例，女性46例。男女比例为1.35比1。男性和女性的总生存期差异显著（p = 0.03015）。诊断时的平均年龄为66.6岁。根据年龄，总生存期为16.4个月。FAB亚型对总生存期有显著影响（p = 0.03015）。总生存期与骨髓原始细胞百分比呈负相关（p = 0.02327）。血细胞减少对总生存期无影响（p = 0.33755）。总体血红蛋白以及不同血红蛋白水平组对总生存期均无影响，分别为（p = 0.12142）和（p = 0.07535）。铁蛋白<500μg/L组的总生存期更好（p = 0.04720）。输血依赖、LDH和白蛋白对总生存期无影响。10例（占9.3%）患者出现白血病转化。死亡率为36.1%。
性别、FAB亚型、骨髓原始细胞百分比以及血清铁蛋白水平对总生存期有影响，而年龄、血红蛋白水平、输血依赖、LDH和白蛋白对总生存期无影响。
