Rhee Jiyoung, Kim Gwi Eon, Lee Chang Hyun, Kwon Jung-Mi, Han Sang-Hoon, Kim Young Suk, Kim Woo-Kun
Department of Internal Medicine, Jeju National University Hospital, Jeju, Korea.
Department of Radiation Oncology, Jeju National University Hospital, Jeju, Korea.
Radiat Oncol J. 2014 Dec;32(4):262-5. doi: 10.3857/roj.2014.32.4.262. Epub 2014 Dec 30.
Tamoxifen and radiotherapy are used in breast cancer treatment worldwide. Radiation recall dermatitis (RRD), induced by tamoxifen, has been rarely reported. Herein, we report a RRD case induced by tamoxifen. A 47-year-old woman had a right quadrantectomy and an axillary lymph node dissection due to breast cancer. The tumor was staged pT2N0; it was hormone receptor positive, and human epidermal growth factor receptor 2 negative. The patient received adjuvant chemotherapy followed by tamoxifen and radiotherapy. After 22 months of tamoxifen, the patient developed a localized heating sensation, tenderness, edema, and redness at the irradiated area of the right breast. The symptoms improved within 1 week without treatment. Three weeks later, however, the patient developed similar symptoms in the same area of the breast. She continued tamoxifen before and during dermatitis, and symptoms resolved within 1 week.
他莫昔芬和放射疗法在全球乳腺癌治疗中均有应用。由他莫昔芬诱发的放射性回忆性皮炎（RRD）鲜有报道。在此，我们报告一例由他莫昔芬诱发的RRD病例。一名47岁女性因乳腺癌接受了右象限切除术和腋窝淋巴结清扫术。肿瘤分期为pT2N0；激素受体阳性，人表皮生长因子受体2阴性。该患者接受了辅助化疗，随后进行他莫昔芬治疗及放射治疗。服用他莫昔芬22个月后，患者右侧乳房放疗区域出现局部发热感、压痛、水肿及发红。未经治疗，症状在1周内有所改善。然而，3周后，患者乳房同一区域出现类似症状。在皮炎发作前及发作期间她继续服用他莫昔芬，症状在1周内消退。
