用于生成具有生物学相关性分子的固载交叉复分解反应和形式上的烷烃复分解反应。
Solid-supported cross-metathesis and a formal alkane metathesis for the generation of biologically relevant molecules.
作者信息
Méndez Luciana, Mata Ernesto G
机构信息
Instituto de Química Rosario (CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario , Suipacha 531, 2000 Rosario, Argentina.
出版信息
ACS Comb Sci. 2015 Feb 9;17(2):81-6. doi: 10.1021/co500176b. Epub 2015 Jan 15.
PMID:25569690
Abstract
Solid-phase synthetic strategies toward the generation of libraries of biologically relevant molecules were developed using olefin cross-metathesis as a key step. It is remarkably the formal alkane metathesis based on a one-pot, microwave-assisted, ruthenium-catalyzed cross-metathesis and reduction to obtain Csp3-Csp3 linkages.
摘要
以烯烃复分解反应作为关键步骤，开发了用于生成具有生物学相关性分子文库的固相合成策略。值得注意的是，这是一种基于一锅法、微波辅助、钌催化的复分解反应和还原反应以获得Csp3-Csp3键的形式上的烷烃复分解反应。
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