Shimizu H, Yamasaki M, Ichimura H, Kurimura O
Dept. of Obstetrics and Gynecology, Kure National Hospital, Hiroshima.
Gan To Kagaku Ryoho. 1989 Dec;16(12):3777-80.
We investigated antitumor effect of cis-diammine-dichloroplatinum (cisplatin or CDDP), cyclophosphamide (CY) and interferon-gamma (gamma-IFN) against argyrophil small cell carcinoma (ASCC) of the uterine cervix using heterotransplanted ASCC tumor (YIK-1) into nude mice, containing HPV 16 DNA in a multicopy integrated form. No tumor growth retardation was observed in the nude mice which received the single administration of CDDP 2 mg/kg, CY 10 mg/kg or gamma-IFN 1 x 10(7) U/kg. However, the combined administration of CDDP and CY, or CDDP, CY and gamma-IFN markedly inhibited the tumor growth. Moreover, with comparison about relative tumor volume between these two groups, the combination of CDDP, CY and gamma-IFN was more effective than that of CDDP and CY. These data suggest that the combination chemotherapy of CDDP, CY and/or gamma-IFN was effective for the suppression of tumor growth in argyrophil small cell carcinoma of the uterine cervix. Further study on the antitumor potentiation of various anti-cancer agent and the combination of them against ASCC is needed.
我们使用异种移植的子宫颈嗜银性小细胞癌（ASCC）肿瘤（YIK-1），其以多拷贝整合形式含有HPV 16 DNA，将其接种到裸鼠体内，研究顺二氨二氯铂（顺铂或CDDP）、环磷酰胺（CY）和干扰素-γ（γ-IFN）对子宫颈嗜银性小细胞癌（ASCC）的抗肿瘤作用。在接受单次给予2 mg/kg CDDP、10 mg/kg CY或1×10⁷ U/kg γ-IFN的裸鼠中未观察到肿瘤生长迟缓。然而，CDDP与CY联合给药，或CDDP、CY与γ-IFN联合给药均显著抑制肿瘤生长。此外，比较这两组之间的相对肿瘤体积，CDDP、CY与γ-IFN联合用药比CDDP与CY联合用药更有效。这些数据表明，CDDP、CY和/或γ-IFN联合化疗对抑制子宫颈嗜银性小细胞癌的肿瘤生长有效。需要进一步研究各种抗癌药物及其联合用药对ASCC的抗肿瘤增效作用。
