人体血小板中受体激活的多磷酸肌醇循环存在严格代谢控制的证据。
Evidence for tight metabolic control of the receptor-activated polyphosphoinositide cycle in human platelets.
作者信息
Steen V M, Tysnes O B, Holmsen H
机构信息
Department of Biochemistry, University of Bergen, Norway.
出版信息
Biochem J. 1989 Oct 15;263(2):621-4. doi: 10.1042/bj2630621.
Abstract
The [32P]PIP2/[32P]PA and the [32P]PIP/[32P]PA relationships were demonstrated to be remarkably similar after stimulation of [32P]Pi-prelabelled platelets for 90 s with various combinations and concentrations of agonists and inhibitors. Thus the activity of the PI and PIP kinases with the corresponding phosphomonoesterases may be tightly controlled during receptor-mediated platelet stimulation involving phospholipase C activation.
摘要
在用各种激动剂和抑制剂的组合及浓度对[32P]Pi预标记的血小板刺激90秒后，[32P]PIP2/[32P]PA和[32P]PIP/[32P]PA的关系被证明非常相似。因此，在涉及磷脂酶C激活的受体介导的血小板刺激过程中，PI和PIP激酶与相应磷酸单酯酶的活性可能受到严格控制。
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