人体血小板中受体激活的多磷酸肌醇循环存在严格代谢控制的证据。
Evidence for tight metabolic control of the receptor-activated polyphosphoinositide cycle in human platelets.
作者信息
Steen V M, Tysnes O B, Holmsen H
机构信息
Department of Biochemistry, University of Bergen, Norway.
出版信息
Biochem J. 1989 Oct 15;263(2):621-4. doi: 10.1042/bj2630621.
Abstract
The [32P]PIP2/[32P]PA and the [32P]PIP/[32P]PA relationships were demonstrated to be remarkably similar after stimulation of [32P]Pi-prelabelled platelets for 90 s with various combinations and concentrations of agonists and inhibitors. Thus the activity of the PI and PIP kinases with the corresponding phosphomonoesterases may be tightly controlled during receptor-mediated platelet stimulation involving phospholipase C activation.
摘要
在用各种激动剂和抑制剂的组合及浓度对[32P]Pi预标记的血小板刺激90秒后，[32P]PIP2/[32P]PA和[32P]PIP/[32P]PA的关系被证明非常相似。因此，在涉及磷脂酶C激活的受体介导的血小板刺激过程中，PI和PIP激酶与相应磷酸单酯酶的活性可能受到严格控制。
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本文引用的文献
1
Activation of human platelet phospholipase C by ionophore A23187 is totally dependent upon cyclo-oxygenase products and ADP.
Biochem J. 1984 Aug 15;222(1):103-10. doi: 10.1042/bj2220103.
2
Kinetics of the thrombin-induced release of calcium (II) by platelets.
Biochemistry. 1973 Jan 16;12(2):282-9. doi: 10.1021/bi00726a017.
3
Synergism between thrombin and epinephrine in human platelets: different dose-response relationships for aggregation and dense granule secretion.
Thromb Haemost. 1985 Oct 30;54(3):680-3.
4
The synergistic effect of serotonin and epinephrine on the human platelet at the level of signal transduction.
FEBS Lett. 1987 Jul 27;219(2):283-8. doi: 10.1016/0014-5793(87)80236-3.
5
Kinetic analysis of guanosine 5'-O-(3-thiotriphosphate) effects on phosphatidylinositol turnover in NRK cell homogenates.
Biochemistry. 1987 Jan 27;26(2):612-22. doi: 10.1021/bi00376a037.
6
Phosphoinositide metabolism in resting and thrombin-stimulated human platelets. Evidence against metabolic heterogeneity.
FEBS Lett. 1987 Jun 22;218(1):68-72. doi: 10.1016/0014-5793(87)81020-7.
7
Turnover of the phosphomonoester groups of polyphosphoinositol lipids in unstimulated human platelets.
Eur J Biochem. 1987 Jul 1;166(1):3-9. doi: 10.1111/j.1432-1033.1987.tb13475.x.
8
Activation of phospholipase C in platelets by platelet activating factor and thrombin causes hydrolysis of a common pool of phosphatidylinositol 4,5-bisphosphate.
Biochim Biophys Acta. 1987 Jul 6;929(2):134-41. doi: 10.1016/0167-4889(87)90168-6.
9
Thrombin-induced phosphoinositide hydrolysis in platelets. Receptor occupancy and desensitization.
Biochem J. 1987 Feb 15;242(1):11-8. doi: 10.1042/bj2420011.
10
Neomycin inhibits agonist-stimulated polyphosphoinositide metabolism and responses in human platelets.
Biochem Biophys Res Commun. 1987 Apr 14;144(1):454-62. doi: 10.1016/s0006-291x(87)80531-4.
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