异氟烷对大鼠模型体感诱发电位的影响。

Effect of isoflurane on somatosensory evoked potentials in a rat model.

作者信息

Kortelainen Jukka, Vipin Ashwati, Mir Hasan, Thakor Nitish, Al-Nashash Hasan, All Angelo

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:4286-9. doi: 10.1109/EMBC.2014.6944572.

DOI:10.1109/EMBC.2014.6944572

Abstract

Somatosensory evoked potentials (SEPs) are widely used in the clinic as well as research to study the functional integrity of the different parts of sensory pathways. However, most general anesthetics, such as isoflurane, are known to suppress SEPs, which might affect the interpretation of the signals. In animal studies, the usage of anesthetics during SEP measurements is inevitable due to which detailed effect of these drugs on the recordings should be known. In this paper, the effect of isoflurane on SEPs was studied in a rat model. Both time and frequency properties of the cortical recordings generated by stimulating the tibial nerve of rat's hindlimb were investigated at three different isoflurane levels. While the anesthetic agent is shown to generally suppress the amplitude of the SEP, the effect was found to be nonlinear influencing more substantially the latter part of waveform. This finding will potentially help us in future work aiming at separating the effects of anesthetics on SEP from those due to injury in the ascending neural pathways.

摘要

体感诱发电位（SEPs）在临床和研究中被广泛用于研究感觉通路不同部分的功能完整性。然而，大多数常用的麻醉剂，如异氟烷，已知会抑制SEPs，这可能会影响信号的解读。在动物研究中，在SEP测量期间使用麻醉剂是不可避免的，因此应该了解这些药物对记录的详细影响。在本文中，在大鼠模型中研究了异氟烷对SEPs的影响。在三种不同的异氟烷水平下，研究了刺激大鼠后肢胫神经所产生的皮层记录的时间和频率特性。虽然麻醉剂通常会抑制SEP的幅度，但发现这种影响是非线性的，对波形的后半部分影响更大。这一发现可能会在我们未来的工作中帮助我们将麻醉剂对SEP的影响与上行神经通路损伤所导致的影响区分开来。