Kerr Matthew S D, Kahn Kevin, Thompson Susan, Hao Stephanie, Bulacio Juan, Gonzalez-Martinez Jorge A, Gale John, Sarma Sridevi V
Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:4391-4. doi: 10.1109/EMBC.2014.6944597.
The neural circuitry underlying fast robust human motor control is not well understood. In this study we record neural activity from multiple stereotactic encephalograph (SEEG) depth electrodes in a human subject while he/she performs a center-out reaching task holding a robotic manipulandum that occasionally introduces an interfering force field. Collecting neural data from humans during motor tasks is rare, and SEEG provides an unusual opportunity to examine neural correlates of movement at a millisecond time scale in multiple brain regions. Time-frequency analysis shows that high frequency activity (50-150 Hz) increases significantly in the left precuneus and left hippocampus when the subject is compensating for a perturbation to their movement. These increases in activity occur with different durations indicating differing roles in the motor control process.
快速稳健的人类运动控制背后的神经回路尚未得到充分理解。在本研究中，我们在一名人类受试者执行中心外伸展任务时，从多个立体定向脑电图（SEEG）深度电极记录神经活动，该受试者手持一个机器人操作器，该操作器偶尔会引入干扰力场。在运动任务期间从人类收集神经数据非常罕见，而SEEG提供了一个独特的机会，可在多个脑区以毫秒时间尺度检查运动的神经相关性。时频分析表明，当受试者补偿其运动受到的扰动时，左楔前叶和左海马体中的高频活动（50 - 150赫兹）显著增加。这些活动增加的持续时间不同，表明在运动控制过程中发挥着不同的作用。
