Hunter R, Merrick M V, Ferrington C, Notghi A, McLuskie R, Christie J E, Goodwin G M
MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park.
Br J Psychiatry. 1989 Jun;154:790-6. doi: 10.1192/bjp.154.6.790.
The cerebral vascular transit time of 17 patients with pre-senile dementia of the Alzheimer type (ATD), nine abstinent patients with alcoholic Korsakoff's psychosis (KOR), and ten age-matched controls was determined by the bolus intravenous injection of pertechnetate. A gamma camera was used to estimate the median transit time (MTT) of the radioactive bolus in a planar (non-tomographic) projection normal to the vertex. The spread of the bolus arriving at the aortic arch was measured independently by a single external detector over the chest, and correction made for the transit time of this input function in calculating the net MTT for the head. Both ATD and KOR groups showed lengthened net MTTs, compatible with reduced cerebral blood flow, and which were correlated with reduced cognitive function. It is concluded that the method employed gives a simple, inexpensive estimate of function-related blood flow to the brain in pre-senile dementia.
通过静脉注射高锝酸盐，测定了17例早老性阿尔茨海默型痴呆（ATD）患者、9例戒酒的酒精性柯萨科夫精神病（KOR）患者以及10例年龄匹配的对照者的脑血管 transit 时间。使用γ相机在垂直于头顶的平面（非断层）投影中估计放射性团注的中位 transit 时间（MTT）。通过胸部上方的单个外部探测器独立测量到达主动脉弓的团注扩散情况，并在计算头部的净MTT时对该输入函数的 transit 时间进行校正。ATD组和KOR组的净MTT均延长，这与脑血流量减少相符，且与认知功能下降相关。得出的结论是，所采用的方法能够对早老性痴呆患者脑内与功能相关的血流量进行简单、廉价的估计。
