用于临床呼气采样的肺泡气挥发性有机化合物提取器。

Alveolar air volatile organic compound extractor for clinical breath sampling.

作者信息

de Silva Geethanga, Beyette Fred R

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:5369-72. doi: 10.1109/EMBC.2014.6944839.

DOI:10.1109/EMBC.2014.6944839

Abstract

Alveolar air Volatile Organic Compound (VOC) extractor is a handheld breath-sampling device for clinical breath analysis. The device consists two main components: (1) An alveolar air separator, (2) A VOC extractor. The alveolar air separator splits exhaled air based on total exhaled air volume directing alveolar air towards the VOC extractor and dead space air to into an exhaust channel. The VOC extractor collects the VOCs from alveolar air into a modified Sold Phase Micro Extraction (SPME) filament. Feasibility of using the SPME filament to collect a quantifiable breath sample directly from exhaled breath is experimentally validated. Exhaled breath acetone is quantified using alveolar air VOC extractor and a GC/MS system.

摘要

肺泡气挥发性有机化合物（VOC）提取器是一种用于临床呼吸分析的手持式呼吸采样设备。该设备由两个主要部件组成：（1）肺泡气分离器，（2）VOC提取器。肺泡气分离器根据呼出气体的总体积对呼出气体进行分离，将肺泡气导向VOC提取器，将死腔气导入排气通道。VOC提取器将肺泡气中的VOC收集到改良的固相微萃取（SPME）纤维中。通过实验验证了使用SPME纤维直接从呼出气体中收集可量化呼吸样本的可行性。使用肺泡气VOC提取器和气相色谱/质谱联用（GC/MS）系统对呼出气体中的丙酮进行定量分析。