A hybrid method for non-rigid registration of intra-operative ultrasound images with pre-operative MR images.

In recent years intra-operative ultrasound images have been used for many procedures in neurosurgery. The registration of intra-operative ultrasound images with preoperative magnetic resonance images is still a challenging problem. In this study a new hybrid method based on residual complexity is proposed for this problem. A new two stages method based on the matching echogenic structures such as sulci is achieved by optimizing the residual complexity (RC) value with quantized coefficients between the ultrasound image and the probabilistic map of MR image. The proposed method is a compromise between feature-based and intensity-based approaches. The evaluation is performed on both a brain phantom and patient data set. The results of the phantom data set confirmed that the proposed method outperforms the accuracy of conventional RC by 39%. Also the mean of fiducial registration errors reached to 1.45, 1.94 mm when the method was applied on phantom and clinical data set, respectively. This hybrid method based on RC enables non-rigid multimodal image registration in a computational time compatible with clinical use as well as being accurate.