Li Min, Liang Chaoyang, Guo Juntang, Ma Yongfu, Zhou Liang, Yang Pu, Yang Gongzheng, Liu Yang
Department of Thoracic Surgery, People's Liberation Army General Hospital, Beijing 100853, China.
Department of Thoracic Surgery, People's Liberation Army General Hospital, Beijing 100853, China. Email:
Zhonghua Wai Ke Za Zhi. 2014 Oct;52(10):734-8.
To probe the clinical application and value of dual source CT quantification volume imaging to forecast lung cancer patients' postoperative pulmonary function changing.
Between June 2012 and June 2013, there were 233 patients (121 male patients and 112 female patients, with a mean age of (53 ± 16) years) who accepted the thoracoscope lobectomy or unilateral holo-lungs pneumonectomy accepted pulmonary function test before and after 3 months of the surgery. CT scan was conducted at both inspiration phase and expiration phase before the surgery and the lung volume of the single lobe, the pixel exponential distribution histogram, and the average lung density were measured after CT scan. The discrepancy and correlation between the preoperative lung volume accepted by CT and preoperative, postoperative pulmonary function index were compared.
The CT volume scan showed that average lung density of the superior part at decubitus position is -(870 ± 22) HU, the inferior part was -(767 ± 16) HU (t = 3.13, P < 0.01). The volume ratio of the right upper lobe, right middle lobe, right lower lobe, left upper lobe, left lower lobe were 20.5%, 10.3%, 23.1%, 24.6%, 21.5%, whole-right lung was 53.9% and whole-left was 46.1%. There were high correlation between CT volume index and preoperative routine pulmonary function index such as total lung capacity, forced vital capacity (FVC), forced expiratory volume in the first second (FEV(1)), residual volume, and FEV(1)/FVC. The highest correlation coefficient were 0.92, 0.76, 0.70, 0.85, 0.56 (t = 3.14, 3.05, 2.86, 3.09, 2.68; all P < 0.01). The highest correlation coefficient for the postoperative pulmonary function index were 0.87, 0.68, 0.75, 0.81, -0.64 (t = 3.10, 2.85, 3.05, 3.02, 2.79; all P < 0.01).
It is feasible to use dual source CT quantification volume imaging to predict lung cancer patients' postoperative pulmonary function alteration, which can provide precise predictive value of these patients. CT quantification volume imaging technology has important clinical application value.
探讨双源CT定量容积成像预测肺癌患者术后肺功能变化的临床应用及价值。
2012年6月至2013年6月，233例患者（男121例，女112例，平均年龄(53±16)岁）接受胸腔镜肺叶切除术或单侧全肺切除术，于术前及术后3个月接受肺功能测试。术前于吸气末及呼气末行CT扫描，扫描后测量单叶肺容积、像素指数分布直方图及平均肺密度。比较术前CT测得的肺容积与术前、术后肺功能指标之间的差异及相关性。
CT容积扫描显示，卧位时上肺平均肺密度为-(870±22)HU，下肺为-(767±16)HU（t=3.13，P<0.01）。右上叶、右中叶、右下叶、左上叶、左下叶的容积比分别为20.5%、10.3%、23.1%、24.6%、21.5%，右全肺为53.9%，左全肺为46.1%。CT容积指数与术前常规肺功能指标如肺总量、用力肺活量（FVC）、第1秒用力呼气量（FEV(1)）、残气量及FEV(1)/FVC之间存在高度相关性。最高相关系数分别为0.92、0.76、0.70、0.85、0.56（t=3.14、3.05、2.86、3.09、2.68；均P<0.01）。术后肺功能指标的最高相关系数分别为0.87、0.68、0.75、0.81、-0.64（t=3.10、2.85、3.05、3.02、2.79；均P<0.01）。
应用双源CT定量容积成像预测肺癌患者术后肺功能改变是可行的，可为这些患者提供精确预测价值。CT定量容积成像技术具有重要的临床应用价值。
Zotero 插件