LINKPHASE3：一种改进的基于家系的相位算法，可稳健应对基因分型和图谱错误。

LINKPHASE3: an improved pedigree-based phasing algorithm robust to genotyping and map errors.

机构信息

Unit of Animal Genomics, GIGA-R, University of Liège (B34), 1 avenue de l'Hôpital, B-4000, Liège, Belgium.

出版信息

Bioinformatics. 2015 May 15;31(10):1677-9. doi: 10.1093/bioinformatics/btu859. Epub 2015 Jan 7.

Abstract

Many applications in genetics require haplotype reconstruction. We present a phasing program designed for large half-sibs families (as observed in plant and animals) that is robust to genotyping and map errors. We demonstrate that it is more efficient than previous versions and other programs, particularly in the presence of genotyping errors.

摘要

许多遗传学应用都需要进行单体型重建。我们提出了一个专为大型半同胞家系（如在植物和动物中观察到的）设计的相位程序，该程序对基因分型和图谱错误具有很强的鲁棒性。我们证明它比以前的版本和其他程序更有效，特别是在存在基因分型错误的情况下。