Miller Larry E, Block Jon E
Miller Scientific Consulting, Inc., Asheville, NC, USA. ; The Jon Block Group, San Francisco, CA, USA.
The Jon Block Group, San Francisco, CA, USA.
Clin Med Insights Arthritis Musculoskelet Disord. 2014 Dec 22;7:49-55. doi: 10.4137/CMAMD.S18356. eCollection 2014.
Numerous nonsurgical interventions have been reported to improve symptoms of knee osteoarthritis (OA) over the short term. However, longer follow-up is required to accurately characterize outcomes such as cost effectiveness and delayed arthroplasty. A total of 553 patients with symptomatic knee OA who previously underwent a single 8-week multimodal treatment program were contacted at 1 year (n = 336) or 2 years (n = 217) follow-up. The percentage of patients who underwent knee arthroplasty was 10% at 1 year and 18% at 2 years following program completion. The treatment program was highly cost effective at $12,800 per quality-adjusted life year at 2 years. Cost effectiveness was maintained under a variety of plausible assumptions and regardless of gender, age, body mass index, disease severity, or knee pain severity. In summary, a single 8-week multimodal knee OA treatment program is cost effective and may lower knee arthroplasty utilization through 2 years follow-up.
据报道，许多非手术干预措施在短期内可改善膝关节骨关节炎（OA）的症状。然而，需要更长时间的随访才能准确描述诸如成本效益和延迟关节置换等结果。共有553例有症状的膝关节OA患者，他们之前接受了为期8周的单一多模式治疗方案，并在1年（n = 336）或2年（n = 217）随访时被联系。在治疗方案完成后1年，接受膝关节置换术的患者比例为10%，2年时为18%。该治疗方案在2年时具有很高的成本效益，每质量调整生命年为12,800美元。在各种合理假设下，无论性别、年龄、体重指数、疾病严重程度或膝关节疼痛严重程度如何，成本效益均得以维持。总之，一个为期8周的单一多模式膝关节OA治疗方案具有成本效益，并且在2年的随访期内可能会降低膝关节置换术的使用率。
